Imipenem, Monohydrate

• CAT Number: R004982
• CAS Number: 74431-23-5
• Molecular Formula: C12H19N3O5S
• Molecular Weight: 317.36
• Purity: ≥95%
• Synonyms: MK-787
• Storage: -20°C
• IUPAC Name: (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;hydrate
• InChI: InChI=1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1
• InChIKey: GSOSVVULSKVSLQ-JJVRHELESA-N
• SMILES: C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.O

Imipenem, Monohydrate（Cat No.:R004982）is a broad-spectrum β-lactam antibiotic used primarily in the treatment of severe bacterial infections. It belongs to the carbapenem class and is highly effective against both Gram-positive and Gram-negative pathogens, including resistant strains. Its mechanism of action involves inhibiting bacterial cell wall synthesis. Imipenem is often co-administered with cilastatin, an inhibitor of renal dehydropeptidase I, to prevent its degradation. This combination ensures enhanced pharmacokinetic properties and maximized antibacterial efficacy, making it a crucial option for treating infections like pneumonia, sepsis, and intra-abdominal infections.

Reference

Guzmán, Flavio, MD. /Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.