IMP-1088

• CAT Number: I015380
• CAS Number: 2059148-82-0
• Molecular Formula: C₂₅H₂₉F₂N₅O
• Molecular Weight: 453.53
• Purity: ≥95%
• Target: DNA/RNA Synthesis
• IUPAC Name: 1-[5-[3,4-difluoro-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-1-methylindazol-3-yl]-N,N-dimethylmethanamine
• InChI: 1S/C25H29F2N5O/c1-15-18(16(2)31(5)28-15)11-12-33-25-19(8-9-21(26)24(25)27)17-7-10-23-20(13-17)22(14-30(3)4)29-32(23)6/h7-10,13H,11-12,14H2,1-6H3
• InChIKey: SOXNKJCQBRQUMS-UHFFFAOYSA-N
• SMILES: CC1=C(C(=NN1C)C)CCOC2=C(C=CC(=C2F)F)C3=CC4=C(C=C3)N(N=C4CN(C)C)C

IMP-1088 (Cat No.: I015380) is a potent and selective inhibitor of N-myristoyltransferases (NMTs), enzymes crucial for protein myristoylation, a key post-translational modification. It has shown strong antiviral activity, particularly against human rhinovirus and poliovirus, by blocking viral replication. IMP-1088 is also used in cancer and infectious disease research, as NMT inhibition disrupts critical cellular pathways. With high specificity and bioavailability, it is a valuable tool for studying protein lipidation, host-pathogen interactions, and potential therapeutic strategies for viral infections and oncology.

Reference

[1]. Aurélie Mousnier, et al. Fragment-derived Inhibitors of Human N-myristoyltransferase Block Capsid Assembly and Replication of the Common Cold Virus. Nat Chem. 2018 Jun;10(6):599-606.