Impurity B of Calcitriol

• CAT Number: I004512
• CAS Number: 66791-71-7
• Molecular Formula: C27H44O3
• Molecular Weight: 416.64
• Purity: ≥95%
• Synonyms: (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
• Target: VD/VDR
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C

Impurity B of Calcitriol (Cat.No:I004512) refers to a specific impurity that may be present in the pharmaceutical compound Calcitriol. It is an undesired substance that can occur during the manufacturing process or storage of Calcitriol. Strict quality control measures are employed to ensure that the levels of Impurity B are within acceptable limits to maintain the purity and efficacy of the medication.

Reference

[1]. Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004)
[2]. Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373.
[3]. Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23.
[4]. Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M. Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.