IMR-1A

• CAT Number: I003197
• CAS Number: 331862-41-0
• Molecular Formula: C13H11NO5S2
• Molecular Weight: 325.36
• Purity: ≥95%
• Target: Stem Cell/Wnt
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: 3 years -20C powder
• InChI: InChI=1S/C13H11NO5S2/c1-18-9-4-7(2-3-8(9)19-6-11(15)16)5-10-12(17)14-13(20)21-10/h2-5H,6H2,1H3,(H,15,16)(H,14,17,20)/b10-5-
• InChIKey: DVBJNSKWHSGTDK-YHYXMXQVSA-N
• SMILES: O=C(O)COC1=CC=C(/C=C(SC(N2)=S)/C2=O)C=C1OC

IMR-1A(CAT: I003197) represents a significant advancement in the field of Notch signaling modulation and drug development. As the metabolite of IMR-1, IMR-1A is intricately linked to the action of its parent compound. IMR-1, belonging to a novel class of Notch inhibitors, targets the transcriptional activation of Notch signaling. This unique mode of action suggests its potential in regulating Notch-dependent processes, which play crucial roles in various physiological and pathological contexts.

Reference

[1]. Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.