For research use only. Not for therapeutic Use.
Incadronate Disodium, also known as Cimadronate and YM-175, is a bone resorption inhibitor. Incadronate disodium inhibits macrophage migration to site of inflammation in vivo and proliferation and causes apoptosis in cancer cells in vitro. Incadronate disodium is a bone density conservation, antitumor and anti-inflammatory agent.
| Catalog Number | M111710 |
| CAS Number | 138330-18-4 |
| Molecular Formula | C8H17NNa2O6P2 |
| Purity | ≥95% |
| Target | Bone Resorption Inhibitor |
| Storage | Store at RT |
| Reference | </br>1:The bisphosphonate incadronate inhibits intraperitoneal dissemination in an in vivo pancreatic cancer model. Takiguchi S, Nishino Y, Inoue K, Ikeda M, Kataoka Y, Matsusue K, Nishiyama K, Iguchi H.Oncol Rep. 2012 Jul;28(1):111-6. doi: 10.3892/or.2012.1757. Epub 2012 Apr 6. PMID: 22484715 </br>2:Collagen maturity, glycation induced-pentosidine, and mineralization are increased following 3-year treatment with incadronate in dogs. Saito M, Mori S, Mashiba T, Komatsubara S, Marumo K.Osteoporos Int. 2008 Sep;19(9):1343-54. doi: 10.1007/s00198-008-0585-3. Epub 2008 Mar 29. PMID: 18373056 </br>3:Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells. Matsunaga S, Iguchi K, Usui S, Hirano K.Anticancer Res. 2007 Mar-Apr;27(2):927-32. PMID: 17465222 Free Article</br>4:Clinical evaluation of incadronate in korean patients with malignancy-associated hypercalcemia: An open-label, multicenter study. Kim SB, Lee JS, Kim HT, Im YH, Kim TW, Ryoo BY, Park YH, Park JO, Park K, Katoh H, Yamamoto M.Curr Ther Res Clin Exp. 2007 May;68(3):193-204. doi: 10.1016/j.curtheres.2007.06.004. PMID: 24683210 Free PMC Article</br>5:Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway. Ishikawa C, Matsuda T, Okudaira T, Tomita M, Kawakami H, Tanaka Y, Masuda M, Ohshiro K, Ohta T, Mori N.Br J Haematol. 2007 Feb;136(3):424-32. PMID: 17233845 </br>6:Inhibition of caveolin-1 expression by incadronate in PC-3 prostate cells. Iguchi K, Matsunaga S, Nakano T, Usui S, Hirano K.Anticancer Res. 2006 Jul-Aug;26(4B):2977-81. PMID: 16886623 Free Article</br>7:Effect of incadronate on proliferation of mesenchymal tumor cells with or without activated Ras mutation. Kawashima H, Ogose A, Hotta T, Ito T, Endo N, Kawashima H, Tamura K, Nakano K.J Exp Clin Cancer Res. 2005 Dec;24(4):617-24. PMID: 16471325 </br>8:Lack of prophylactic effect of incadronate on skeletal lesions associated with implants of prostate cancer. Hikosaka A, Futakuchi M, Ogiso T, Suzuki S, Kohri K, Shirai T.Eur Urol. 2006 Jan;49(1):176-82. Epub 2005 Nov 8. PMID: 16310925 </br>9:The protective effects of incadronate on inflammation and joint destruction in established rat adjuvant arthritis. Zhao H, Liu S, Huang D, Xu Q, Shuto T, Iwamoto Y.Rheumatol Int. 2006 Jun;26(8):732-40. Epub 2005 Oct 20. PMID: 16237529 </br>10:Nitrogen-containing bisphosphonate incadronate augments the inhibitory effect of farnesyl transferase inhibitor tipifarnib on the growth of fresh and cloned myeloma cells in vitro. Ochiai N, Yamada N, Uchida R, Fuchida S, Okano A, Okamoto M, Ashihara E, Inaba T, Shimazaki C.Leuk Lymphoma. 2005 Nov;46(11):1619-25. PMID: 16236616 |
