INCB-057643

• CAT Number: I020260
• CAS Number: 1820889-23-3
• Molecular Formula: C₂₀H₂₁N₃O₅S
• Molecular Weight: 415.46
• Purity: ≥95%
• Target: Apoptosis
• IUPAC Name: 2,2,4-trimethyl-8-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-methylsulfonyl-1,4-benzoxazin-3-one
• InChI: InChI=1S/C20H21N3O5S/c1-20(2)19(25)23(4)15-9-11(29(5,26)27)8-13(17(15)28-20)14-10-22(3)18(24)16-12(14)6-7-21-16/h6-10,21H,1-5H3
• InChIKey: VZSAMEOETVNDQH-UHFFFAOYSA-N
• SMILES: CC1(C(=O)N(C2=CC(=CC(=C2O1)C3=CN(C(=O)C4=C3C=CN4)C)S(=O)(=O)C)C)C

INCB-057643（Cat No.:I020260）is a selective inhibitor of the protein kinase IDO1 (indoleamine 2,3-dioxygenase 1), an enzyme involved in the metabolic pathway that regulates tryptophan levels and immune responses. By inhibiting IDO1, INCB-057643 aims to enhance anti-tumor immunity by preventing the local immune suppression commonly seen in tumor microenvironments. This compound has shown promise in preclinical studies and early clinical trials for improving the efficacy of immunotherapies, particularly in cancers with high IDO1 expression. INCB-057643 represents a potential therapeutic strategy for restoring immune function in cancer treatment.

Reference

[1]. Matthew C. Stubbs, et al. Abstract 5071: Preclinical characterization of the potent and selective BET inhibitor INCB057643 in models of hematologic malignancies. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5071.