For research use only. Not for therapeutic Use.
INCB059872 is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor. INCB059872 can be used for the research of myeloid leukemia[1].
INCB059872 (25 nM; 48 hours; 293T cells) increases enhancer activity and gene expression[1].
INCB059872 (25 nM; 24 hours; THP-1 cells) makes THP-1 show a growth defect within one cell doubling time or approximately 3 days.
INCB059872 (THP-1 cells) regulates PRO-seq analysis identifies genes and enhancers[1].
INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 days; C57BL/6J mice) makes single-cell RNA-seq revealing changes in bone marrow progenitor populations[1].
| Catalog Number | I045251 |
| CAS Number | 1802909-49-4 |
| Synonyms | 1-[[4-(methoxymethyl)-4-[[[(1R,2S)-2-phenylcyclopropyl]amino]methyl]piperidin-1-yl]methyl]cyclobutane-1-carboxylic acid |
| Molecular Formula | C23H34N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H34N2O3/c1-28-17-22(15-24-20-14-19(20)18-6-3-2-4-7-18)10-12-25(13-11-22)16-23(21(26)27)8-5-9-23/h2-4,6-7,19-20,24H,5,8-17H2,1H3,(H,26,27)/t19-,20+/m0/s1 |
| InChIKey | WBPWDDPSYSUQJA-VQTJNVASSA-N |
| SMILES | COCC1(CCN(CC1)CC2(CCC2)C(=O)O)CNC3CC3C4=CC=CC=C4 |
| Reference | [1]. Johnston G, et al. Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia. Gene. 2020;752:144758. |
