INCB13739

• CAT Number: I043321
• CAS Number: 869974-19-6
• Molecular Formula: C28H25N3O4
• Molecular Weight: 467.52
• Purity: ≥95%
• Synonyms: N-methyl-5-[4-[1-[(1R)-3-oxospiro[2-benzofuran-1,3′-pyrrolidine]-1′-carbonyl]cyclopropyl]phenyl]pyridine-2-carboxamide
• IUPAC Name: N-methyl-5-[4-[1-[(1R)-3-oxospiro[2-benzofuran-1,3'-pyrrolidine]-1'-carbonyl]cyclopropyl]phenyl]pyridine-2-carboxamide
• InChI: InChI=1S/C28H25N3O4/c1-29-24(32)23-11-8-19(16-30-23)18-6-9-20(10-7-18)27(12-13-27)26(34)31-15-14-28(17-31)22-5-3-2-4-21(22)25(33)35-28/h2-11,16H,12-15,17H2,1H3,(H,29,32)/t28-/m0/s1
• InChIKey: BDQCDIWFPIDPQU-NDEPHWFRSA-N
• SMILES: CNC(=O)C1=NC=C(C=C1)C2=CC=C(C=C2)C3(CC3)C(=O)N4CC[C@]5(C4)C6=CC=CC=C6C(=O)O5

INCB13739（Cat No.:I043321）is a selective inhibitor of the enzyme Janus kinase 1 (JAK1), which is involved in the signaling of various cytokines and growth factors critical for immune response and inflammation. By inhibiting JAK1, INCB13739 aims to reduce the overactive immune signaling seen in autoimmune diseases and certain cancers. It has shown potential in treating conditions such as rheumatoid arthritis, inflammatory bowel disease, and certain hematologic malignancies. INCB13739 is being investigated in clinical trials to assess its safety, efficacy, and ability to modulate immune responses in these diseases.