For research use only. Not for therapeutic Use.
INCB3344(CAT: I001055) is a novel, potent, and selective small molecule antagonist targeting the mouse CCR2 receptor. It effectively inhibits the binding of CCL2 (monocyte chemoattractant protein-1) to CCR2 on monocytes with nanomolar potency. By blocking this chemokine-receptor interaction, INCB3344 disrupts monocyte recruitment to sites of inflammation, making it a valuable tool in inflammation and immunology research. It is particularly useful for studying the role of the CCR2/CCL2 axis in inflammatory diseases, including atherosclerosis, autoimmune disorders, and cancer. INCB3344 provides insights into therapeutic strategies for modulating immune cell trafficking and resolving chronic inflammatory conditions.
| CAS Number | 1262238-11-8 |
| Synonyms | N-[2-[[(3S,4S)-1-[4-(1,3-benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxypyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide |
| Molecular Formula | C29H34F3N3O6 |
| Purity | ≥95% |
| Target | Immunology/Inflammation |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 10 nM [1] |
| IUPAC Name | N-[2-[[(3S,4S)-1-[4-(1,3-benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxypyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide |
| InChI | InChI=1S/C29H34F3N3O6/c1-2-39-25-16-35(21-8-10-28(38,11-9-21)19-6-7-23-24(13-19)41-17-40-23)15-22(25)34-26(36)14-33-27(37)18-4-3-5-20(12-18)29(30,31)32/h3-7,12-13,21-22,25,38H,2,8-11,14-17H2,1H3,(H,33,37)(H,34,36)/t21?,22-,25-,28?/m0/s1 |
| InChIKey | MZEOSVPWMSEFPW-XYCDVDSTSA-N |
| SMILES | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)C2=CC(=CC=C2)C(F)(F)F)C3CCC(CC3)(C4=CC5=C(C=C4)OCO5)O |
