For research use only. Not for therapeutic Use.
Indacrinone (Cat No.: I007307) is a loop diuretic with uricosuric properties, used primarily in the treatment of hypertension and edema associated with heart failure or kidney disorders. It inhibits the Na⁺/K⁺/2Cl⁻ co-transporter in the thick ascending limb of the loop of Henle, promoting sodium and water excretion. Uniquely, indacrinone also enhances uric acid excretion, counteracting the hyperuricemia commonly induced by other diuretics. Its dual action makes it valuable in managing fluid retention while minimizing the risk of gout, especially in sensitive patient populations.
| CAS Number | 57296-63-6 |
| Synonyms | Indacrinone; Indacrinona [Spanish]; Indacrinone; Indacrinonum; Indacrinonum [INN-Latin]; Indacrinonum [Latin]; MK 196; MK-196; Acidum indacrinicum; Acidum indacrinicum [INN-Latin]; Indacrinona. Indacrinona [INN-Spanish].;Acetic acid, ((2,3-dihydro-6, |
| Molecular Formula | C18H14Cl2O4 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 3 years -20C powder |
| InChI | InChI=1S/C18H14Cl2O4/c1-18(11-5-3-2-4-6-11)8-10-7-12(24-9-13(21)22)15(19)16(20)14(10)17(18)23/h2-7H,8-9H2,1H3,(H,21,22) |
| InChIKey | PRKWVSHZYDOZLP-UHFFFAOYSA-N |
| SMILES | O=C(O)COC1=CC2=C(C(C(C3=CC=CC=C3)(C)C2)=O)C(Cl)=C1Cl |
| Reference | </br>1:Cochlear effects of indacrinone are not altered by penicillin. Rybak LP, Whitworth C, Morris C, Scott V, Kanno H.Hear Res. 1995 May;85(1-2):122-6. PMID: 7559168 </br>2:Conductive chloride flux across amphibian skin: inhibition by indacrinone and cobalt ion. Beaujean V, Crabbé J.Biochim Biophys Acta. 1992 Feb 17;1104(1):174-8. PMID: 1550845 </br>3:Hepatotoxicity of DR-3438, tienilic acid, indacrinone and furosemide studied in vitro. Takagi S, Takayama S, Onodera T.Toxicol Lett. 1991 Mar;55(3):287-93. PMID: 2003271 </br>4:Determination of the optical purity of indacrinone by proton nuclear magnetic resonance spectroscopy using chiral lanthanide chelates. Hanna GM, Lau-Cam CA.J Pharm Biomed Anal. 1989;7(8):919-28. PMID: 2562290 </br>5:Ototoxicity of indacrinone is stereospecific. Rybak LP, Whitworth C.Hear Res. 1987 Dec;31(2):169-74. PMID: 3446673 </br>6:Radioimmunoassays for the enantiomeric components of indacrinone and their phenolic metabolites. Vyas KP, Hichens M, Mulcahy WS, Hand EL.J Immunoassay. 1987;8(2-3):179-201. PMID: 3624493 </br>7:Indacrinone (MK-196)–a specific inhibitor of the voltage-dependent Cl- permeability in toad skin. Dürr JE, Larsen EH.Acta Physiol Scand. 1986 Jun;127(2):145-53. PMID: 3088914 </br>8:Optical purity determination and (1)H-NMR spectral simplification with lanthanide shift reagents – VIII. An indacrinone precursor, 6,7-dichloro-5-methoxy-2-methyl-2-phenyl-1-indanone. Hatzis A, Rothchild R.J Pharm Biomed Anal. 1986;4(4):443-9. PMID: 16867580 </br>9:Opposite effects of indacrinone (MK-196) on sodium and chloride conductance of amphibian skin. Nagel W, Beauwens R, Crabbé J.Pflugers Arch. 1985 Apr;403(4):337-43. PMID: 3925431 </br>10:Antihypertensive and biochemical effects of indacrinone enantiomers. Jain AK, Michael R, Ryan JR, McMahon FG.Pharmacotherapy. 1984 Sep-Oct;4(5):278-83. PMID: 6504709 |
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