For research use only. Not for therapeutic Use.
Indacrinone is a loop diuretic. It can be used in patients of gout with hypertension as an antihypertensive because it decreases reabsorption of uric acid.
| Catalog Number | I007307 |
| CAS Number | 57296-63-6 |
| Synonyms | Indacrinone; Indacrinona [Spanish]; Indacrinone; Indacrinonum; Indacrinonum [INN-Latin]; Indacrinonum [Latin]; MK 196; MK-196; Acidum indacrinicum; Acidum indacrinicum [INN-Latin]; Indacrinona. Indacrinona [INN-Spanish].;Acetic acid, ((2,3-dihydro-6, |
| Molecular Formula | C18H14Cl2O4 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 3 years -20C powder |
| InChI | InChI=1S/C18H14Cl2O4/c1-18(11-5-3-2-4-6-11)8-10-7-12(24-9-13(21)22)15(19)16(20)14(10)17(18)23/h2-7H,8-9H2,1H3,(H,21,22) |
| InChIKey | PRKWVSHZYDOZLP-UHFFFAOYSA-N |
| SMILES | O=C(O)COC1=CC2=C(C(C(C3=CC=CC=C3)(C)C2)=O)C(Cl)=C1Cl |
| Reference | </br>1:Cochlear effects of indacrinone are not altered by penicillin. Rybak LP, Whitworth C, Morris C, Scott V, Kanno H.Hear Res. 1995 May;85(1-2):122-6. PMID: 7559168 </br>2:Conductive chloride flux across amphibian skin: inhibition by indacrinone and cobalt ion. Beaujean V, Crabbé J.Biochim Biophys Acta. 1992 Feb 17;1104(1):174-8. PMID: 1550845 </br>3:Hepatotoxicity of DR-3438, tienilic acid, indacrinone and furosemide studied in vitro. Takagi S, Takayama S, Onodera T.Toxicol Lett. 1991 Mar;55(3):287-93. PMID: 2003271 </br>4:Determination of the optical purity of indacrinone by proton nuclear magnetic resonance spectroscopy using chiral lanthanide chelates. Hanna GM, Lau-Cam CA.J Pharm Biomed Anal. 1989;7(8):919-28. PMID: 2562290 </br>5:Ototoxicity of indacrinone is stereospecific. Rybak LP, Whitworth C.Hear Res. 1987 Dec;31(2):169-74. PMID: 3446673 </br>6:Radioimmunoassays for the enantiomeric components of indacrinone and their phenolic metabolites. Vyas KP, Hichens M, Mulcahy WS, Hand EL.J Immunoassay. 1987;8(2-3):179-201. PMID: 3624493 </br>7:Indacrinone (MK-196)–a specific inhibitor of the voltage-dependent Cl- permeability in toad skin. Dürr JE, Larsen EH.Acta Physiol Scand. 1986 Jun;127(2):145-53. PMID: 3088914 </br>8:Optical purity determination and (1)H-NMR spectral simplification with lanthanide shift reagents – VIII. An indacrinone precursor, 6,7-dichloro-5-methoxy-2-methyl-2-phenyl-1-indanone. Hatzis A, Rothchild R.J Pharm Biomed Anal. 1986;4(4):443-9. PMID: 16867580 </br>9:Opposite effects of indacrinone (MK-196) on sodium and chloride conductance of amphibian skin. Nagel W, Beauwens R, Crabbé J.Pflugers Arch. 1985 Apr;403(4):337-43. PMID: 3925431 </br>10:Antihypertensive and biochemical effects of indacrinone enantiomers. Jain AK, Michael R, Ryan JR, McMahon FG.Pharmacotherapy. 1984 Sep-Oct;4(5):278-83. PMID: 6504709 |
