Indapamide

• CAT Number: A000360
• CAS Number: 26807-65-8
• Molecular Formula: C16H16ClN3O3S
• Molecular Weight: 365.8
• Purity: ≥95%
• Synonyms: 26807-65-8; Noranat; Veroxil; Lozol; Indaflex
• Target: Potassium Channel
• Solubility: >13mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)
• InChIKey: NDDAHWYSQHTHNT-UHFFFAOYSA-N
• SMILES: CC1CC2=CC=CC=C2N1NC(=O)C3=CC(=C(C=C3)Cl)S(=O)(=O)N

Indapamide is a thiazide-like diuretic generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.

Reference

1: Kobalava DZ, Shavarova KE. [Clinical Features of Arterial Hypertension in the
Elderly and Senile Age and the Rationale for Using the Combination of
Amlodipine/Indapamide-retard]. Kardiologiia. 2017 Aug;57(8):60-70. Russian.
PubMed PMID: 29041894.

2: Kobalava Z, Troitskaya E, Ezhova N. [Fixed-Drug Combination Amlodipine,
Indapamide and Perindopril: New Horizons of Antihypertensive Therapy].
Kardiologiia. 2017 Apr;57(4):79-88. Russian. PubMed PMID: 28762910.

3: Glezer On Behalf Of The Forsage Program Participants MG. [Adherence of
Patients to Antihypertensive Therapy With Combination of Perindopril and
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4: Hanon O, Caillard L, Chaussade E, Hernandorena I, Boully C. Blood
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6: Karpov YA; FORTISSIMO physicians. Erratum to: Full-dose Perindopril/Indapamide
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7: Okamura K, Shirai K, Totake N, Okuda T, Urata H. Prospective direct comparison
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8: ábrahám G, Dézsi CA. The Antihypertensive Efficacy of the Triple Fixed
Combination of Perindopril, Indapamide, and Amlodipine: The Results of the PETRA
Study. Adv Ther. 2017 Jul;34(7):1753-1763. doi: 10.1007/s12325-017-0572-1. Epub
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9: Pande A. Renoprotection with indapamide, additional feature to look for.
Indian Heart J. 2017 Mar – Apr;69(2):284-285. doi: 10.1016/j.ihj.2017.01.018.
Epub 2017 Jan 31. PubMed PMID: 28460782; PubMed Central PMCID: PMC5414977.

10: Mourad JJ, Amodeo C, de Champvallins M, Brzozowska-Villatte R, Asmar R; study
coordinators, investigators. Blood pressure-lowering efficacy and safety of
perindopril/indapamide/amlodipine single-pill combination in patients with
uncontrolled essential hypertension: a multicenter, randomized, double-blind,
controlled trial. J Hypertens. 2017 Jul;35(7):1481-1495. doi:
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