For research use only. Not for therapeutic Use.
Indecainide (Cat.No:I007309) is a rarely used antidysrhythmic. Indecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.
| Catalog Number | I007309 |
| CAS Number | 74517-78-5 |
| Synonyms | Ricainid, Indecainida, Indecainidum, Decabid, Ricainide;9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide |
| Molecular Formula | C20H24N2O |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide |
| InChI | InChI=1S/C20H24N2O/c1-14(2)22-13-7-12-20(19(21)23)17-10-5-3-8-15(17)16-9-4-6-11-18(16)20/h3-6,8-11,14,22H,7,12-13H2,1-2H3,(H2,21,23) |
| InChIKey | UCEWGESNIULAGX-UHFFFAOYSA-N |
| SMILES | CC(C)NCCCC1(C2=CC=CC=C2C3=CC=CC=C31)C(=O)N |
| Reference | </br>1:Effect of indecainide in patients with left ventricular dysfunction. Giardina EV, Saroff AL, Schneider M.Clin Pharmacol Ther. 1990 Nov;48(5):582-9. PMID: 2225716 </br>2:Antiarrhythmic and hemodynamic evaluation of indecainide and procainamide in nonsustained ventricular tachycardia. Pratt CM, Francis MJ, Seals AA, Zoghbi W, Young JB.Am J Cardiol. 1990 Jul 1;66(1):68-74. PMID: 2193498 </br>3:Indecainide: effects on arrhythmias, electrophysiology, and cardiovascular dynamics. Holland DR, Lacefield WB, Gonzales CR, Johnston SR, Turk JA.J Cardiovasc Pharmacol. 1989 Sep;14(3):454-61. PMID: 2476626 </br>4:Indecainide for treatment of ventricular ectopic depolarizations: efficacy, pharmacokinetics, hemodynamic effects and safety. Salerno DM, Krejci J, Granrud G, Hodges M.J Am Coll Cardiol. 1988 Apr;11(4):843-50. PMID: 3351153 Free Article</br>5:Noninvasive evaluation of indecainide for serious ventricular tachyarrhythmia. Podrid PJ, Hohnloser S, Lown B.Am J Cardiol. 1988 Apr 1;61(10):764-9. PMID: 2451415 </br>6:Chronic dietary oncogenicity studies of indecainide in rats and mice. Sandusky GE, Usher RW, Tamura RN.Fundam Appl Toxicol. 1987 Oct;9(3):436-47. PMID: 3692003 </br>7:Indecainide compared with quinidine for chronic stable ventricular arrhythmias secondary to coronary artery disease or to cardiomyopathy. Giardina EG, Zaim S, Saroff AL, Kirschenbaum M.Am J Cardiol. 1987 Sep 1;60(7):584-9. PMID: 2442993 </br>8:Antiarrhythmic effects of oral indecainide in patients with ventricular tachyarrhythmias. Macina G, Turitto G, Stavens C, Fontaine J, Hariman R, Ursell S, el-Sherif N.Clin Cardiol. 1987 Jun;10(6):357-61. PMID: 3594958 Free Article</br>9:Efficacy of oral and intravenous indecainide in ventricular arrhythmias. Nestico PF, Morganroth J, Horowitz LN, Mulhern C.Am J Cardiol. 1987 Jun 1;59(15):1332-6. PMID: 3296725 </br>10:Antiarrhythmic effects of indecainide in a drug-resistant population with ventricular tachycardia at programmed electrical stimulation. Miura DS, Wynn J, Keefe D, Laux B, Somberg JC.Am Heart J. 1987 Jan;113(1):65-9. PMID: 3799443 |
