For research use only. Not for therapeutic Use.
Indeloxazine HCl (Cat.No:I007311) acts as a serotonin releasing agent, norepinephrine reuptake inhibitor, and NMDA receptor antagonist. It has been found to enhance acetylcholine release in the rat forebrain through activation of the 5-HT4 receptor via its action as a serotonin releasing agent. Indeloxazine hydrochloride is an antidepressant and cerebral activator.
| Catalog Number | I007311 |
| CAS Number | 65043-22-3 |
| Synonyms | Indeloxazine hydrochloride; Indeloxazine HCl; Indeloxazine; CI 874; CI-874l; CI874l; YM 08054-1; YM08054-1.;2-((1H-Inden-7-yloxy)methyl)morpholine hydrochloride |
| Molecular Formula | C14H18ClNO2 |
| Purity | ≥95% |
| Target | NMDA Receptor Antagonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 2-(3H-inden-4-yloxymethyl)morpholine;hydrochloride |
| InChI | InChI=1S/C14H17NO2.ClH/c1-3-11-4-2-6-14(13(11)5-1)17-10-12-9-15-7-8-16-12;/h1-4,6,12,15H,5,7-10H2;1H |
| InChIKey | KEBHLNDPKPIPLI-UHFFFAOYSA-N |
| SMILES | C1COC(CN1)COC2=CC=CC3=C2CC=C3.Cl |
| Reference | </br>1:Neurochemical and behavioral characterization of potential antidepressant properties of indeloxazine hydrochloride. Yamaguchi T, Ohyama M, Suzuki M, Ozawa Y, Hatanaka K, Hidaka K, Yamamoto M.Neuropharmacology. 1998 Sep;37(9):1169-76. PMID: 9833647 </br>2:Facilitation of acetylcholine release in rat frontal cortex by indeloxazine hydrochloride: involvement of endogenous serotonin and 5-HT4 receptors. Yamaguchi T, Suzuki M, Yamamoto M.Naunyn Schmiedebergs Arch Pharmacol. 1997 Dec;356(6):712-20. PMID: 9453456 </br>3:A case of eosinophilic pustular folliculitis (Ofuji/’s disease) induced by patch and challenge tests with indeloxazine hydrochloride. Kimura K, Ezoe K, Yokozeki H, Katayama I, Nishioka K.J Dermatol. 1996 Jul;23(7):479-83. PMID: 8772029 </br>4:Indeloxazine hydrochloride improves impairment of passive avoidance performance after fluid percussion brain injury in rats. Yamaguchi T, Ozawa Y, Suzuki M, Yamamoto M, Nakamura T, Yamaura A.Neuropharmacology. 1996 Mar;35(3):329-36. PMID: 8783208 </br>5:[The preventive effect of indeloxazine hydrochloride to the sexual dysfunction caused by anti-androgenergic agent (allylestrenol)]. Horita H, Kumamoto Y, Satoh Y, Suzuki N, Wada H, Shibuya A, Adachi H, Kurohata T, Tsukamoto T.Nihon Hinyokika Gakkai Zasshi. 1995 May;86(5):1044-50. Japanese. PMID: 7541089 Free Article</br>6:Effects of indeloxazine hydrochloride, a cerebral activator, on passive avoidance learning impaired by disruption of cholinergic transmission in rats. Yamamoto M, Ooyama M, Ozawa Y, Okada M, Tada S, Yamaguchi T, Endo H.Neuropharmacology. 1993 Jul;32(7):695-701. PMID: 8395664 </br>7:Anti-hypoxic and anti-ischemic actions of indeloxazine hydrochloride and its optical isomers: possible involvement of cerebral energy metabolism. Shimizu-Sasamata M, Terai M, Harada M, Yamamoto M.Arch Int Pharmacodyn Ther. 1993 Jul-Aug;324:33-46. PMID: 8297184 </br>8:Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine hydrochloride on ischemia-induced changes in brain monoamines and their metabolites in gerbils. Haba K, Ogawa N, Asanuma M, Hirata H, Mori A.J Neural Transm Gen Sect. 1992;88(3):187-98. PMID: 1384558 </br>9:Effects of indeloxazine hydrochloride on behavioral and biochemical changes in the chronic phase of focal cerebral ischemia in rats. Shimizu-Sasamata M, Yamamoto M, Okada M, Yamaguchi T, Tamura A.Arch Int Pharmacodyn Ther. 1991 Nov-Dec;314:74-89. PMID: 1824190 </br>10:Effects of indeloxazine hydrochloride on sleep in normal humans. Kajimura N, Mizuki Y, Kai S, Suetsugi M, Sekimoto M, Fujii S, Yamada M, Yamadera H, Okuma T.Methods Find Exp Clin Pharmacol. 1991 Mar;13(2):139-45. PMID: 2072811 |
