Indimitecan

• CAT Number: I007314
• CAS Number: 915360-05-3
• Molecular Formula: C25H21N3O6
• Molecular Weight: 459.45
• Purity: ≥95%
• Synonyms: 20-(3-imidazol-1-ylpropyl)-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
• InChI: InChI=1S/C25H21N3O6/c1-31-18-8-14-17(11-19(18)32-2)25(30)28(6-3-5-27-7-4-26-12-27)23-15-9-20-21(34-13-33-20)10-16(15)24(29)22(14)23/h4,7-12H,3,5-6,13H2,1-2H3
• InChIKey: GCILEJUNEYIABW-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CCCN6C=CN=C6)OC

Indimitecan（Cat No.:I007314）is a potent chemotherapy drug belonging to the camptothecin class of anticancer agents. It functions by inhibiting the enzyme topoisomerase I, which is essential for DNA replication and repair. By interfering with this enzyme, indimitecan induces DNA damage, leading to cell death, particularly in rapidly dividing cancer cells. It has shown promise in treating various cancers, including colorectal, ovarian, and lung cancers. Indimitecan is typically administered intravenously and is being studied in clinical trials for its effectiveness and safety profile in combination therapies for cancer treatment.