Indocyanine Green (~90%)

For research use only. Not for therapeutic Use.

  • CAT Number: R048884
  • CAS Number: 3599-32-4
  • Molecular Formula: C₄₃H₄₇N₂NaO₆S₂
  • Molecular Weight: 774.96
  • Purity: ≥95%
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Indocyanine Green (CAS 3599-32-4), also known as Cardio-Green and Fox, is a tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.


Catalog Number R048884
CAS Number 3599-32-4
Synonyms

2-[7-[1,3-Dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrien-1-yl]-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz[e]indolium Inner Salt Sodium Salt; 4,5-Benzoindotricarbocyanine; Cardio Green; ICG; IR 125; Indocyanin Green; NK 2

Molecular Formula C₄₃H₄₇N₂NaO₆S₂
Purity ≥95%
Storage -20°C
IUPAC Name sodium;4-[(2E)-2-[(2E,4E,6E)-7-[1,1-dimethyl-3-(4-sulfonatobutyl)benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonate
InChI InChI=1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1
InChIKey MOFVSTNWEDAEEK-UHFFFAOYSA-M
SMILES CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)CCCCS(=O)(=O)[O-])C=CC=CC=CC=C4C(C5=C(N4CCCCS(=O)(=O)[O-])C=CC6=CC=CC=C65)(C)C)C.[Na+]
Reference

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1: Nagata J, Fukunaga Y, Akiyoshi T, Konishi T, Fujimoto Y, Nagayama S, Yamamoto N, Ueno M. Colonic Marking With Near-Infrared, Light-Emitting, Diode-Activated Indocyanine Green for Laparoscopic Colorectal Surgery. Dis Colon Rectum. 2016 Feb;59(2):e14-8. doi: 10.1097/DCR.0000000000000542. PubMed PMID: 26734978.<br />
2: Yuen K, Miura T, Sakai I, Kiyosue A, Yamashita M. Intraoperative Fluorescence Imaging for Detection of Sentinel Lymph Nodes and Lymphatic Vessels during Open Prostatectomy using Indocyanine Green. J Urol. 2015 Aug;194(2):371-7. doi: 10.1016/j.juro.2015.01.008. Epub 2015 Jan 10. PubMed PMID: 25584996.<br />
3: Yang K, Mu L, Liu Y, Peng Z, Li G. [APPLICATION VALUE OF INDOCYANINE GREEN ANGIOGRAPHY IN FLAP RECONSTRUCTIVE SURGERY]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2015 Sep;29(9):1113-6. Chinese. PubMed PMID: 26750010.<br />
4: Pirie CG, Alario A. Use of indocyanine green and sodium fluorescein for anterior segment angiography in ophthalmologically normal cats. Am J Vet Res. 2015 Oct;76(10):897-903. doi: 10.2460/ajvr.76.10.897. PubMed PMID: 26413828.<br />
5: Esposito G, Burkhardt JK, Bozinov O, Regli L. Indocyanine green videoangiography for the identification of superficial temporal artery branches in EC-IC bypass surgery. Acta Neurochir (Wien). 2016 Mar;158(3):565-70. doi: 10.1007/s00701-016-2703-x. PubMed PMID: 26783025.<br />
6: Fekrazad R, Poorsattar Bejeh Mir A, Ghasemi Barghi V, Shams-Ghahfarokhi M. Eradication of C. albicans and T. rubrum with photoactivated indocyanine green, Citrus aurantifolia essential oil and fluconazole. Photodiagnosis Photodyn Ther. 2015 Jun;12(2):289-97. doi: 10.1016/j.pdpdt.2014.12.009. Epub 2015 Jan 5. PubMed PMID: 25573286.<br />
7: Suganami A, Iwadate Y, Shibata S, Yamashita M, Tanaka T, Shinozaki N, Aoki I, Saeki N, Shirasawa H, Okamoto Y, Tamura Y. Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection. Int J Pharm. 2015 Dec 30;496(2):401-6. doi: 10.1016/j.ijpharm.2015.10.001. PubMed PMID: 26453781.<br />
8: Mundra V, Peng Y, Rana S, Natarajan A, Mahato RI. Micellar formulation of indocyanine green for phototherapy of melanoma. J Control Release. 2015 Dec 28;220(Pt A):130-40. doi: 10.1016/j.jconrel.2015.10.029. PubMed PMID: 26482083.<br />
9: Jheng PR, Lu KY, Yu SH, Mi FL. Free DOX and chitosan-N-arginine conjugate stabilized indocyanine green nanoparticles for combined chemophotothermal therapy. Colloids Surf B Biointerfaces. 2015 Dec 1;136:402-12. doi: 10.1016/j.colsurfb.2015.09.032. PubMed PMID: 26440756.<br />
10: Nishizawa M, Igari K, Kudo T, Toyofuku T, Inoue Y, Uetake H. A Comparison of the Regional Circulation in the Feet between Dialysis and Non-Dialysis Patients using Indocyanine Green Angiography. Scand J Surg. 2016 Aug 24. pii: 1457496916666412. [Epub ahead of print] PubMed PMID: 27557983.<br />

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