Indorenate

• CAT Number: I029351
• CAS Number: 73758-06-2
• Molecular Formula: C13H16N2O3
• Molecular Weight: 248.28
• Purity: 98%
• Synonyms: Indorenate
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: methyl 3-amino-2-(5-methoxy-1H-indol-3-yl)propanoate
• InChI: InChI=1S/C13H16N2O3/c1-17-8-3-4-12-9(5-8)11(7-15-12)10(6-14)13(16)18-2/h3-5,7,10,15H,6,14H2,1-2H3
• InChIKey: YFEDJMLMWJSRJJ-UHFFFAOYSA-N
• SMILES: COC1=CC2=C(C=C1)NC=C2C(CN)C(=O)OC

Indorenate（Cat No.:I029351）is a drug that acts as a selective antagonist at the dopamine D2 receptor, which plays a key role in the regulation of mood, motor control, and reward pathways in the brain. It has been explored for its potential therapeutic applications in the treatment of neurological and psychiatric conditions, particularly in managing disorders like schizophrenia and Parkinson’s disease. Indorenate’s ability to modulate dopamine activity may help alleviate symptoms associated with these disorders, such as motor dysfunction and psychosis. However, further research and clinical trials are needed to assess its safety, efficacy, and therapeutic potential.

Reference

1. Bravo G, Ibarra A, Guizar-Sahagún G, Rojas G, Hong E. Indorenate improves motor function in rats with chronic spinal cord injury. Basic Clin Pharmacol Toxicol. 2007 Jan;100(1):67-70. doi: 10.1111/j.1742-7843.2007.00004.x. PMID: 17214613.
2. Martínez-Mota L, Estrada-Camarena E, López-Rubalcava C. Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors. Psychopharmacology (Berl). 2002 Dec;165(1):60-6. doi: 10.1007/s00213-002-1222-z. Epub 2002 Oct 23. PMID: 12474119.
3. Fernández-Guasti A, Escalante A, Hong E, Agmo A. Behavioural actions of the serotonergic anxiolytic indorenate. Pharmacol Biochem Behav. 1990 Sep;37(1):83-8. doi: 10.1016/0091-3057(90)90045-j. PMID: 1979877.