For research use only. Not for therapeutic Use.
INF39(CAT: I007333) is a compound known for its inhibitory effects on the NLRP3 inflammasome. It is a non-toxic and irreversible inhibitor that has been shown to decrease the release of interleukin-1β from macrophages, indicating its potential anti-inflammatory activity. INF39 directly targets the NLRP3 inflammasome and interferes with its activation in cells, as demonstrated by bioluminescence resonance energy transfer experiments. These findings suggest that INF39 may have therapeutic applications in the treatment of inflammatory bowel disease and other inflammatory conditions where NLRP3 activation is implicated.
| Catalog Number | I007333 |
| CAS Number | 866028-26-4 |
| Synonyms | INF39; INF-39; INF 39.;ethyl 2-(2-chlorobenzyl)acrylate |
| Molecular Formula | C12H13ClO2 |
| Purity | ≥95% |
| Target | NOD-like Receptor (NLR) |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| InChI | InChI=1S/C12H13ClO2/c1-3-15-12(14)9(2)8-10-6-4-5-7-11(10)13/h4-7H,2-3,8H2,1H3 |
| InChIKey | VTAOWWAFBSFWSG-UHFFFAOYSA-N |
| SMILES | ClC1=C(CC(C(OCC)=O)=C)C=CC=C1 |
| Reference | </br>1:Cocco M, Pellegrini C, Martínez-Banaclocha H, Giorgis M, Marini E, Costale A, Miglio G, Fornai M, Antonioli L, López-Castejón G, Tapia-Abellán A, Angosto D, Hafner-Bratkovič I, Regazzoni L, Blandizzi C, Pelegrín P, Bertinaria M. Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2017 Apr 24. doi: 10.1021/acs.jmedchem.6b01624. [Epub ahead of print] PubMed PMID: 28410442. |
