For research use only. Not for therapeutic Use.
INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction[1][2].
INF4E (compound 9) preventes both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner[3].
INF4E significantly reduces the in infarct size and lactate dehydrogenase release and improvement in postischemic left ventricular pressure[1].
INF4E attenuates the formation of NLRP3 inflammasome complex was induced by myocardial IR (ischemia/reperfusion) in a time-dependent way[1].
| Catalog Number | I033377 |
| CAS Number | 88039-46-7 |
| Synonyms | ethyl 2-[(2-chlorophenyl)-hydroxymethyl]prop-2-enoate |
| Molecular Formula | C12H13ClO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H13ClO3/c1-3-16-12(15)8(2)11(14)9-6-4-5-7-10(9)13/h4-7,11,14H,2-3H2,1H3 |
| InChIKey | BSRPDXCMAOIUOO-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C(=C)C(C1=CC=CC=C1Cl)O |
| Reference | [1]. Shi Y, et al. NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages. Int Immunopharmacol. 2021 Mar;92:107358. [2]. Mezzaroma E,et al. NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases. Molecules. 2021 Feb 12;26(4):976. [3]. occo M, et al. Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J Med Chem. 2014 Dec 26;57(24):10366-82. |
