For research use only. Not for therapeutic Use.
INF55(CAT: I007334) is a compound known as a NorA efflux pump inhibitor. NorA is an efflux pump found in certain bacteria, such as Staphylococcus aureus, that is responsible for pumping out various antibiotics from the bacterial cell, leading to antibiotic resistance. By inhibiting the NorA efflux pump, INF55 may prevent the removal of antibiotics from bacterial cells, thereby enhancing the effectiveness of antibiotics against NorA-expressing bacteria. This mechanism of action makes INF55 potentially useful in combating antibiotic-resistant bacterial infections.
| Catalog Number | I007334 |
| CAS Number | 4993-87-7 |
| Synonyms | INF55;5-Nitro-2-phenyl-1H-indole |
| Molecular Formula | C14H10N2O2 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 5-nitro-2-phenyl-1H-indole |
| InChI | InChI=1S/C14H10N2O2/c17-16(18)12-6-7-13-11(8-12)9-14(15-13)10-4-2-1-3-5-10/h1-9,15H |
| InChIKey | UNJRQDPTLDVHOR-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=CC3=C(N2)C=CC(=C3)[N+](=O)[O-] |
| Reference | </br>1:On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials. Dolla NK, Chen C, Larkins-Ford J, Rajamuthiah R, Jagadeesan S, Conery AL, Ausubel FM, Mylonakis E, Bremner JB, Lewis K, Kelso MJ.Aust J Chem. 2015;67:1471-1480. PMID: 26806960 Free PMC Article</br>2:Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. Tomkiewicz D, Casadei G, Larkins-Ford J, Moy TI, Garner J, Bremner JB, Ausubel FM, Lewis K, Kelso MJ.Antimicrob Agents Chemother. 2010 Aug;54(8):3219-24. doi: 10.1128/AAC.01715-09. Epub 2010 May 24. PMID: 20498327 Free PMC Article |
