For research use only. Not for therapeutic Use.
Inflachromene(CAT: R065393) is a small molecule inhibitor known for its anti-inflammatory properties. It specifically targets and inhibits the TRPV4 (Transient Receptor Potential Vanilloid 4) ion channel, which is involved in various physiological processes, including the regulation of osmotic pressure, temperature sensitivity, and inflammatory responses. By inhibiting TRPV4, inflachromene can reduce inflammation and has shown potential in treating conditions associated with excessive inflammation, such as certain types of arthritis and inflammatory pain. Due to its targeted action, inflachromene is of significant interest in pharmacological research for developing new anti-inflammatory therapies. Its ability to modulate TRPV4 activity makes it a valuable tool in studying the role of this ion channel in health and disease.
| Catalog Number | R065393 |
| CAS Number | 908568-01-4 |
| Synonyms | 5-hydroxy-9,9-dimethyl-15-phenyl-8-oxa-13,15,17-triazatetracyclo[8.7.0.02,7.013,17]heptadeca-2(7),3,5,10-tetraene-14,16-dione |
| Molecular Formula | C21H19N3O4 |
| Purity | ≥95% |
| IUPAC Name | 5-hydroxy-9,9-dimethyl-15-phenyl-8-oxa-13,15,17-triazatetracyclo[8.7.0.02,7.013,17]heptadeca-2(7),3,5,10-tetraene-14,16-dione |
| InChI | InChI=1S/C21H19N3O4/c1-21(2)16-10-11-22-19(26)23(13-6-4-3-5-7-13)20(27)24(22)18(16)15-9-8-14(25)12-17(15)28-21/h3-10,12,18,25H,11H2,1-2H3 |
| InChIKey | VVOXDJYPDCSQMI-UHFFFAOYSA-N |
| SMILES | CC1(C2=CCN3C(=O)N(C(=O)N3C2C4=C(O1)C=C(C=C4)O)C5=CC=CC=C5)C |
| Reference | [1]. Lee HH, et, al. A validated UPLC-MS/MS method for pharmacokinetic study of inflachromene, a novel microglia inhibitor. J Pharm Biomed Anal. 2019 Mar 20; 166: 183-188. [2]. Lee S, et, al. A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Nat Chem Biol. 2014 Dec; 10(12): 1055-60. |
