Ingenol 3,20-dibenzoate

• CAT Number: I029366
• CAS Number: 59086-90-7
• Molecular Formula: C34H36O7
• Molecular Weight: 556.66
• Purity: 98%
• Synonyms: Ingenol 3,20-dibenzoate; Ingenol 3,20 dibenzoate; IDB
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: [(1S,4S,5S,6R,9S,10R,12R,14R)-4-benzoyloxy-5,6-dihydroxy-3,11,11,14-tetramethyl-15-oxo-7-tetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dienyl]methyl benzoate
• InChI: InChI=1S/C34H36O7/c1-19-17-33-20(2)15-25-26(32(25,3)4)24(28(33)36)16-23(18-40-30(37)21-11-7-5-8-12-21)27(35)34(33,39)29(19)41-31(38)22-13-9-6-10-14-22/h5-14,16-17,20,24-27,29,35,39H,15,18H2,1-4H3/t20-,24+,25-,26+,27-,29+,33+,34+/m1/s1
• InChIKey: GIMKEHNOTHXONN-NXBFFCPZSA-N
• SMILES: C[C@@H]1C[C@@H]2[C@@H](C2(C)C)[C@@H]3C=C([C@H]([C@]4([C@@]1(C3=O)C=C([C@@H]4OC(=O)C5=CC=CC=C5)C)O)O)COC(=O)C6=CC=CC=C6

Ingenol 3,20-dibenzoate（Cat No.:I029366）is a synthetic derivative of ingenol, a natural product derived from the sap of the Euphorbia genus. This compound exhibits potential anti-inflammatory and anti-cancer properties by modulating immune responses and inducing apoptosis in tumor cells. Ingenol 3,20-dibenzoate has been studied for its effects on skin lesions, particularly in the treatment of actinic keratosis and non-melanoma skin cancers. Its mechanism involves activation of protein kinase C and subsequent pathways that lead to cell death and immune activation. This compound offers a promising avenue for developing topical therapies for skin malignancies.

Reference

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