Ingenol Mebutate

• CAT Number: I004798
• CAS Number: 75567-37-2
• Molecular Formula: C25H34O6
• Molecular Weight: 430.51
• Purity: ≥95%
• Synonyms: Ingenol Mebutate;3-Ingenyl Angelate;PEP005;Picato®
• Target: TGF-beta/Smad
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IUPAC Name: [(1S,4S,5S,6R,9S,10R,12R,14R)-5,6-dihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-15-oxo-4-tetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dienyl] (Z)-2-methylbut-2-enoate
• InChI: InChI=1S/C25H34O6/c1-7-12(2)22(29)31-21-13(3)10-24-14(4)8-17-18(23(17,5)6)16(20(24)28)9-15(11-26)19(27)25(21,24)30/h7,9-10,14,16-19,21,26-27,30H,8,11H2,1-6H3/b12-7-/t14-,16+,17-,18+,19-,21+,24+,25+/m1/s1
• InChIKey: VDJHFHXMUKFKET-WDUFCVPESA-N
• SMILES: C/C=C(/C)\C(=O)O[C@H]1C(=C[C@@]23[C@@]1([C@@H](C(=C[C@H](C2=O)[C@H]4[C@H](C4(C)C)C[C@H]3C)CO)O)O)C

Ingenol Mebutate(CAT: I004798) is a diterpene ester derived from the sap of Euphorbia peplus, widely utilized in oncology and dermatological research. It acts as a dual-action agent, promoting cell death in rapidly proliferating cells while simultaneously inducing an immune response to target remaining abnormal cells. Ingenol Mebutate is particularly studied for its role in the treatment of actinic keratosis and as a model compound for exploring cancer therapies. Its ability to activate protein kinase C (PKC) pathways makes it a valuable tool for investigating cellular signaling, apoptosis, and immune modulation. Its high specificity and efficacy provide insights into topical treatments and novel therapeutic strategies.