For research use only. Not for therapeutic Use.
INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity[1][2].
When INO5042 is added to endothelial cells, a shift of velocities is observed towards fast speeds (from 3-5 to 7-11 microm/sec). The same results is significantly found when neutrophils, alone or along with endothelium, has been submitted to INO5042, the number of stickers and rollers being reduced as well[1].
| Catalog Number | I013376 |
| CAS Number | 14782-19-5 |
| Synonyms | 2-(furan-2-yl)benzo[f][1,3]benzothiazole-4,9-dione |
| Molecular Formula | C15H7NO3S |
| Purity | ≥95% |
| InChI | InChI=1S/C15H7NO3S/c17-12-8-4-1-2-5-9(8)13(18)14-11(12)16-15(20-14)10-6-3-7-19-10/h1-7H |
| InChIKey | VJKZUTFFMNSTTD-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)SC(=N3)C4=CC=CO4 |
| Reference | [1]. Renard M, et al. Induced changes of leukocyte slow rolling in an in flow pharmacological model of adhesion to endothelial cells. Biorheology. 2003;40(1-3):173-8. [2]. Fosse C, et, al. Parameters and mechanistic studies on the oxidative ring cleavage of synthetic heterocyclic naphthoquinones by Streptomyces strains. Appl Microbiol Biotechnol. 2004 Sep;65(4):446-56. |
