For research use only. Not for therapeutic Use.
iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects[1].
iNOs-IN-1 (YPW) (12.5, 25 and 50 µM; 2 hours) can significantly reduce NO production in LPS-treated RAW 264.7 cells[1].
iNOs-IN-1 (12.5, 25 and 50 µM; 2 hours) inhibits IL-6 production and iNOS protein expression in LPS-treated RAW 264.7 mouse macrophages[1].
| Catalog Number | I043974 |
| Synonyms | (2S)-3-(3a,7a-dihydro-1H-indol-3-yl)-2-[[(2S)-1-[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid |
| Molecular Formula | C25H28N4O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H30N4O5/c26-19(12-15-7-9-17(30)10-8-15)24(32)29-11-3-6-22(29)23(31)28-21(25(33)34)13-16-14-27-20-5-2-1-4-18(16)20/h1-2,4-5,7-10,14,18-22,27,30H,3,6,11-13,26H2,(H,28,31)(H,33,34)/t18?,19-,20?,21+,22+/m1/s1 |
| InChIKey | QFQRIUSUXVQVLV-WHVLVZFFSA-N |
| SMILES | C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)N)C(=O)NC(CC3=CNC4C3C=CC=C4)C(=O)O |
| Reference | [1]. Peng Y, et al. Identification and molecular mechanism of a tri-peptide inhibitor targeting iNOS from duck embryo protein hydrolysates by experimental and bioinformatics studies. Bioorg Chem. 2022;122:105736. |
