Insulin sensitizer C59

• CAT Number: I047720
• CAS Number: 2761446-81-3
• Molecular Formula: C16H18Cl2N2O
• Molecular Weight: 325.23
• Purity: ≥95%
• IUPAC Name: N-(4,5-dichloropyridin-2-yl)adamantane-1-carboxamide
• InChI: InChI=1S/C16H18Cl2N2O/c17-12-4-14(19-8-13(12)18)20-15(21)16-5-9-1-10(6-16)3-11(2-9)7-16/h4,8-11H,1-3,5-7H2,(H,19,20,21)
• SMILES: C1C2CC3CC1CC(C2)(C3)C(=O)NC4=NC=C(C(=C4)Cl)Cl

Insulin sensitizer C59 enhances insulin-stimulated GLUT4 translocation and glucose uptake in glucose storage tissue by targeting Unc119b. Moreover, C59 treatment improves glucose tolerance in rodent models of insulin resistance.
KEYWORDS: Insulin sensitizer C59 | Supplier | Insulin sensitizer | C 59 | C-59 | CAS [2761446-81-3] | Glucose | SRC | Inhibitor | Enzymes | Unc119B | Insulin resistance | Type II diabetes | GLUT4 translocation enhancer

Reference

TC Yin et al. Insulin sensitization by small molecules enhancing GLUT4 translocation. Cell Chem Biol. 2023 Aug 17;30(8):933-942.e6.

A Mittal et al. FRI617 Targeting Unc119b For Insulin Sensitization. J Endocr Soc. 2023 Oct 5;7(Suppl 1):bvad114.839.