INT-777

• CAT Number: I000733
• CAS Number: 1199796-29-6
• Molecular Formula: C27H46O5
• Molecular Weight: 450.7
• Purity: ≥95%
• Target: G protein-coupled Bile Acid Receptor 1
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: Store at -20°C
• IC50: 0.82 uM [1]
• InChIKey: NPBCMXATLRCCLF-IRRLEISYSA-N

INT-777 (Cat.No:I000733) is a potent and selective agonist of the Takeda G protein-coupled receptor 5 (TGR5), also known as GPBAR1. TGR5 activation has been linked to various metabolic benefits, including glucose homeostasis, lipid metabolism, and anti-inflammatory effects. INT-777 is being investigated for its potential therapeutic applications in metabolic disorders such as type 2 diabetes and obesity.

Reference

[1]. Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.
[2]. Thomas C, et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009 Sep;10(3):167-77.