For research use only. Not for therapeutic Use.
Inupadenant hydrochloride (EOS–850)(CAT: I029398) is an orally bioavailable, highly selective antagonist of the adenosine A₂A receptor (A₂AR). By inhibiting A₂AR on T–lymphocytes, inupadenant aims to counteract the immunosuppressive effects of tumor–derived adenosine, thereby enhancing anti–tumor immune responses. It has demonstrated potent anti–tumor activity in preclinical studies and is currently under investigation in clinical trials for the treatment of advanced solid tumors, including non–small cell lung cancer (NSCLC). These trials are evaluating its safety, tolerability, and efficacy as a monotherapy and in combination with other cancer treatments.
| CAS Number | 2411004-22-1 |
| Synonyms | 7-amino-10-[2-[4-[2,4-difluoro-5-[2-[(S)-methylsulfinyl]ethoxy]phenyl]piperazin-1-yl]ethyl]-4-(furan-2-yl)-12-thia-3,5,6,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-11-one;hydrochloride |
| Molecular Formula | C25H27ClF2N8O4S2 |
| Purity | ≥95% |
| IUPAC Name | 7-amino-10-[2-[4-[2,4-difluoro-5-[2-[(S)-methylsulfinyl]ethoxy]phenyl]piperazin-1-yl]ethyl]-4-(furan-2-yl)-12-thia-3,5,6,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-11-one;hydrochloride |
| InChI | InChI=1S/C25H26F2N8O4S2.ClH/c1-41(37)12-11-39-19-14-17(15(26)13-16(19)27)33-7-4-32(5-8-33)6-9-34-22-20(40-25(34)36)23-29-21(18-3-2-10-38-18)31-35(23)24(28)30-22;/h2-3,10,13-14H,4-9,11-12H2,1H3,(H2,28,30);1H/t41-;/m0./s1 |
| InChIKey | DDVRGKDOXQCEQN-YZNDQDBRSA-N |
| SMILES | CS(=O)CCOC1=C(C=C(C(=C1)N2CCN(CC2)CCN3C4=C(C5=NC(=NN5C(=N4)N)C6=CC=CO6)SC3=O)F)F.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
