Inz-5

• CAT Number: I017878
• CAS Number: 1585214-21-6
• Molecular Formula: C₁₈H₁₄F₄N₆
• Molecular Weight: 390.34
• Purity: ≥95%
• Target: Fungal
• Storage: 4°C, stored under nitroge
• IUPAC Name: 3-[2-fluoro-5-(trifluoromethyl)phenyl]-7-methyl-1-[(2-methyltetrazol-5-yl)methyl]indazole
• InChI: InChI=1S/C18H14F4N6/c1-10-4-3-5-12-16(13-8-11(18(20,21)22)6-7-14(13)19)25-28(17(10)12)9-15-23-26-27(2)24-15/h3-8H,9H2,1-2H3
• InChIKey: MMEFXWUINPSTPN-UHFFFAOYSA-N
• SMILES: CC1=C2C(=CC=C1)C(=NN2CC3=NN(N=N3)C)C4=C(C=CC(=C4)C(F)(F)F)F

Inz-5（Cat No.:I017878）is a potent and selective inhibitor of the MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) enzyme. It specifically targets MALT1’s protease activity, which is crucial for regulating the NF-κB signaling pathway involved in immune cell activation, inflammation, and oncogenesis. By inhibiting MALT1, Inz-5 suppresses the activation of NF-κB, thereby reducing the proliferation of immune cells and mitigating inflammatory responses. This makes Inz-5 a promising candidate for the treatment of autoimmune diseases and certain cancers, particularly those involving aberrant NF-κB signaling.

Reference

[1]. Vincent BM, et al. A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. Cell Chem Biol. 2016 Aug 18;23(8):978-991.