Iobenguane I 131

• CAT Number: I029404
• CAS Number: 77679-27-7
• Molecular Formula: C8H10131IN3
• Molecular Weight: 279.09
• Purity: 98%
• Synonyms: 3-Iodobenzylguanidine, 131I-MIBG, Azedra, I-131 MIBG, Iobenguane (131I) , Iobenguane I 131, MIBG, MIBG-(131 I), Ultratrace iobenguane I131
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (m-Iodo-(sup 131)I-benzyl)guanidine
• InChI: 1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)/i9+4
• InChIKey: PDWUPXJEEYOOTR-JRGAVVOBSA-N
• SMILES: c1ccc(cc1[131I])CNC(N)=N

Iobenguane I 131 is a guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.

Reference

1: Kotecka-Blicharz A, Hasse-Lazar K, Handkiewicz-Junak D, Gawlik T, Pawlaczek A, Oczko-Wojciechowska M, Michalik B, Szpak-Ulczok S, Krajewska J, Jurecka-Lubieniecka B, Jarząb B. 131-I MIBG therapy of malignant pheochromocytoma and paraganglioma tumours – a single-centre study. Endokrynol Pol. 2018;69(3):246-251. doi: 10.5603/EP.a2018.0024. Epub 2018 Apr 12. PubMed PMID: 29645065.
2: Inaki A, Yoshimura K, Murayama T, Imai Y, Kuribayashi Y, Higuchi T, Jinguji M, Shiga T, Kinuya S. A phase I clinical trial for [(131)I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma: a study protocol. J Med Invest. 2017;64(3.4):205-209. doi: 10.2152/jmi.64.205. PubMed PMID: 28954983.
3: Carrasquillo JA, Pandit-Taskar N, Chen CC. I-131 Metaiodobenzylguanidine Therapy of Pheochromocytoma and Paraganglioma. Semin Nucl Med. 2016 May;46(3):203-14. doi: 10.1053/j.semnuclmed.2016.01.011. Review. PubMed PMID: 27067501.
4: Vöö S, Bucerius J, Mottaghy FM. I-131-MIBG therapies. Methods. 2011 Nov;55(3):238-45. doi: 10.1016/j.ymeth.2011.10.006. Epub 2011 Oct 25. Review. PubMed PMID: 22056346.