For research use only. Not for therapeutic Use.
Iodixanol is a contrast agent. It is commonly used as a contrast agent during coronary angiography. It is the only iso-osmolar contrast agent, with an osmolality of 290 mOsm/kg H2O—the same as blood.
| Catalog Number | R012686 |
| CAS Number | 92339-11-2 |
| Synonyms | 5,5’-[(2-Hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N’-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide; 2-5410-3A; OptiPrep; Visipaque; |
| Molecular Formula | C35H44I6N6O15 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 5-[acetyl-[3-[N-acetyl-3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodoanilino]-2-hydroxypropyl]amino]-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide |
| InChI | InChI=1S/C35H44I6N6O15/c1-13(52)46(30-26(38)20(32(59)42-3-15(54)9-48)24(36)21(27(30)39)33(60)43-4-16(55)10-49)7-19(58)8-47(14(2)53)31-28(40)22(34(61)44-5-17(56)11-50)25(37)23(29(31)41)35(62)45-6-18(57)12-51/h15-19,48-51,54-58H,3-12H2,1-2H3,(H,42,59)(H,43,60)(H,44,61)(H,45,62) |
| InChIKey | NBQNWMBBSKPBAY-UHFFFAOYSA-N |
| SMILES | CC(=O)N(CC(CN(C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I)C(=O)C)O)C2=C(C(=C(C(=C2I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I |
| Reference | </br>1:Delayed genital blisters following iodixanol administration. Zhang W, Yuan W, Yuan HL, Yang XL, Xie H.Clin Toxicol (Phila). 2017 May 2:1-2. doi: 10.1080/15563650.2017.1319952. [Epub ahead of print] PMID: 28463024 </br>2:Comparison of the nephrotoxic effects of iodixanol versus iohexol in patients with chronic heart failure undergoing coronary angiography or angioplasty. Song T, Song M, Ge Z, Li Y, Shi P, Sun M.J Interv Cardiol. 2017 Apr 19. doi: 10.1111/joic.12381. [Epub ahead of print] PMID: 28421628 </br>3:Comparison of Iodixanol and Iopromide in Patients With Renal Insufficiency and Congestive Heart Failure Undergoing Coronary Angiography by Hemodynamic Monitoring. Qian G, Yang YQ, Dong W, Cao F, Chen YD.Angiology. 2017 Jan 1:3319717701868. doi: 10.1177/0003319717701868. [Epub ahead of print] PMID: 28401790 </br>4:An isocratic hydrophilic interaction liquid chromatographic method for simultaneous determination of iodixanol and its related impurities in drug substance. Rondon BD, Cassiano NM, Cass QB.J Pharm Biomed Anal. 2017 Jun 5;140:342-346. doi: 10.1016/j.jpba.2017.03.046. Epub 2017 Mar 24. PMID: 28395244 </br>5:Effects of supplementation of iodixanol to semen extender on quality and fertilization ability of frozen-thawed Thai native bull sperm. Chuawongboon P, Sirisathien S, Pongpeng J, Sakhong D, Nagai T, Vongpralub T.Anim Sci J. 2017 Mar 30. doi: 10.1111/asj.12798. [Epub ahead of print] PMID: 28370846 </br>6:Iodixanol as a Contrast Agent in a Fibrin Hydrogel for Endodontic Applications. Hertig G, Zehnder M, Woloszyk A, Mitsiadis TA, Ivica A, Weber FE.Front Physiol. 2017 Mar 15;8:152. doi: 10.3389/fphys.2017.00152. eCollection 2017. PMID: 28360862 Free PMC Article</br>7:Comparison of 270 Versus 320 mg I/mL of Iodixanol in 1 Image Assessment of Both Renal Arteries and Veins With Dual-Energy Spectral CT Imaging in Late Arterial Phase and Their Influence on Renal Function. Zhou K, He J, Qu F, Fan H, Ma Y, Shi T, Zhou Z, Zhu B.J Comput Assist Tomogr. 2017 Feb 24. doi: 10.1097/RCT.0000000000000595. [Epub ahead of print] PMID: 28240640 </br>8:The effect of aspirated barium sulfate, iodixanol, and diatrizoic acid on survival and lung injury in a lagomorph model. Siddiqui MT, Litts JK, Cheney DM, Kuhn MA, Nativ-Zeltzer N, Belafsky PC.Laryngoscope. 2017 May;127(5):E148-E152. doi: 10.1002/lary.26494. Epub 2017 Feb 24. PMID: 28233902 </br>9:The cryoprotective effect of iodixanol in buffalo semen cryopreservation. Swami DS, Kumar P, Malik RK, Saini M, Kumar D, Jan MH.Anim Reprod Sci. 2017 Apr;179:20-26. doi: 10.1016/j.anireprosci.2017.01.012. Epub 2017 Feb 3. PMID: 28189350 </br>10:Randomized, Double-Blind Study Comparing Patient Comfort and Safety Between Iodixanol 320 mg I/mL and Iopamidol 370 mg I/mL in Patients Undergoing Peripheral Arteriography – The COMFORT II Trial. Rosenberg C, Martínez-Rodrigo JJ, Lonjedo Vicent E, Macho J, Lim L, Todoran TM; Peripheral Discomfort Study Investigator Panel..J Invasive Cardiol. 2017 Jan;29(1):9-15. PMID: 28045670 Free Article |
