For research use only. Not for therapeutic Use.
Iodoacetyl-LC-biotin is a biotinylated electrophile probe that can be used to investigate the scope and characteristics of protein covalent binding to subcellular proteomes[1][2].
Iodoacetyl-LC-biotin (IAB) (50-200 μM; 6-24 h) increases LDH leakage in HEK293 cells in a time- and dose-dependant manner[1].
IAB (50-200 µM; 24 h) causes the release of cytochrome c from the mitochondria to the cytosol in HEK293 cells[1].
| Catalog Number | R003017 |
| CAS Number | 93285-75-7 |
| Synonyms | 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[6-[(2-iodoacetyl)amino]hexyl]pentanamide |
| Molecular Formula | C18H31IN4O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C18H31IN4O3S/c19-11-16(25)21-10-6-2-1-5-9-20-15(24)8-4-3-7-14-17-13(12-27-14)22-18(26)23-17/h13-14,17H,1-12H2,(H,20,24)(H,21,25)(H2,22,23,26)/t13-,14-,17-/m0/s1 |
| InChIKey | DNXDWMHPTVQBIP-ZQIUZPCESA-N |
| SMILES | C1C2C(C(S1)CCCCC(=O)NCCCCCCNC(=O)CI)NC(=O)N2 |
| Reference | [1]. Wong HL, et, al. Mitochondrial protein targets of thiol-reactive electrophiles. Chem Res Toxicol. 2008 Apr;21(4):796-804. [2]. Davis KA, et, al. Staining of cell surface human CD4 with 2′-F-pyrimidine-containing RNA aptamers for flow cytometry. Nucleic Acids Res. 1998 Sep 1;26(17):3915-24. |
