Ionizable lipid-1

• CAT Number: I040870
• CAS Number: 2055939-68-7
• Molecular Formula: C58H114N2O5
• Molecular Weight: 919.54
• Purity: ≥95%
• Synonyms: ditridecan-7-yl 10-[3-(dimethylamino)propyl-octanoylamino]nonadecanedioate
• InChI: InChI=1S/C58H114N2O5/c1-8-13-18-27-38-48-56(61)60(52-41-51-59(6)7)53(42-32-28-23-25-30-39-49-57(62)64-54(44-34-19-14-9-2)45-35-20-15-10-3)43-33-29-24-26-31-40-50-58(63)65-55(46-36-21-16-11-4)47-37-22-17-12-5/h53-55H,8-52H2,1-7H3
• InChIKey: VBFYPCGDFUFVCZ-UHFFFAOYSA-N
• SMILES: CCCCCCCC(=O)N(CCCN(C)C)C(CCCCCCCCC(=O)OC(CCCCCC)CCCCCC)CCCCCCCCC(=O)OC(CCCCCC)CCCCCC

Ionizable Lipid-1 (CAT: I040870) is an ionizable lipid with a pKa of 6.16, which allows it to transition between protonated and deprotonated states under physiological conditions. This property makes it ideal for forming lipid nanoparticles (LNPs) with a bilayer structure. The lipid nanoparticles can encapsulate nucleic acids like mRNA, offering a stable and efficient delivery system for gene therapies and vaccines. By adjusting the ionization state of Ionizable Lipid-1, LNPs can be optimized for cellular uptake and controlled release. This compound plays a key role in pharmaceutical research focused on advanced drug delivery systems, especially for mRNA-based vaccines and gene editing therapies.