For research use only. Not for therapeutic Use.
IOWH-032 (Cat.No:I000692) is an experimental small molecule inhibitor that targets the cystic fibrosis transmembrane conductance regulator (CFTR) channel, specifically designed for cholera treatment. By inhibiting CFTR-mediated chloride secretion, IOWH032 aims to reduce the severe diarrhea associated with cholera, which is caused by Vibrio cholerae. It represents a novel therapeutic approach focusing on symptom control rather than pathogen eradication. IOWH032 is instrumental in studies exploring the regulation of ion channels in intestinal epithelial cells and its potential broader applications in other secretory diarrheas.
| Catalog Number | I000692 |
| CAS Number | 1191252-49-9 |
| Synonyms | 3-(3,5-dibromo-4-oxocyclohexa-2,5-dien-1-ylidene)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide |
| Molecular Formula | C22H15Br2N3O4 |
| Purity | ≥95% |
| Target | Anti-infection |
| Solubility | in DMSO > 10 mM |
| Storage | Store at -20℃ |
| IC50 | 1.01 uM (CHO-CFTR FLIPR) |
| IUPAC Name | 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide |
| InChI | InChI=1S/C22H15Br2N3O4/c23-17-10-14(11-18(24)19(17)28)20-26-22(31-27-20)21(29)25-12-13-6-8-16(9-7-13)30-15-4-2-1-3-5-15/h1-11,28H,12H2,(H,25,29) |
| InChIKey | DSFNLJXHXBIKDS-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC(=O)C3=NC(=NO3)C4=CC(=C(C(=C4)Br)O)Br |
