IOWH-032

• CAT Number: I000692
• CAS Number: 1191252-49-9
• Molecular Formula: C22H15Br2N3O4
• Molecular Weight: 545.18
• Purity: ≥95%
• Synonyms: 3-(3,5-dibromo-4-oxocyclohexa-2,5-dien-1-ylidene)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide
• Target: CFTR
• Solubility: in DMSO > 10 mM
• Storage: Store at -20℃
• IC50: 1.01 uM (CHO-CFTR FLIPR) [1]
• IUPAC Name: 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide
• InChI: InChI=1S/C22H15Br2N3O4/c23-17-10-14(11-18(24)19(17)28)20-26-22(31-27-20)21(29)25-12-13-6-8-16(9-7-13)30-15-4-2-1-3-5-15/h1-11,28H,12H2,(H,25,29)
• InChIKey: DSFNLJXHXBIKDS-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC(=O)C3=NC(=NO3)C4=CC(=C(C(=C4)Br)O)Br

IOWH-032 (Cat.No:I000692) is a potent and selective inhibitor of spleen tyrosine kinase (SYK), a key signaling molecule involved in immune cell activation and inflammatory responses. By inhibiting SYK, IOWH-032 modulates immune system function and shows potential therapeutic effects in autoimmune diseases, allergic disorders, and certain types of cancer.

Reference

[1]. Doyle K, et al. Inhibitors Of The CFTR Chloride Ion Channel As Potential Treatment For
Acute Secretory Diarrhea: Development Of 5-membered Heterocycles Suitable For Pre-clinical Evaluation

[2]. de Hostos EL, et al. Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25.