IOX1

• CAT Number: I004180
• CAS Number: 5852-78-8
• Molecular Formula: C₁₀H₇NO₃
• Molecular Weight: 189.17
• Purity: ≥95%
• Synonyms: 8-hydroxyquinoline-5-carboxylic acid
• Target: Histone Demethylase
• Solubility: DMSO: ≥ 24 mg/mL
• Storage: Store at +4C
• IC50: 0.6/0.1 uM(KDM4A/KDM3A) [1]
• InChI: InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
• InChIKey: JGRPKOGHYBAVMW-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O

IOX1 (Cat No.:I004180) is a potent inhibitor of 2OG oxygenases, specifically targeting the JmjC demethylases. It acts as a broad-spectrum inhibitor, meaning it can inhibit a wide range of enzymes belonging to the 2OG oxygenase family. JmjC demethylases are enzymes involved in the removal of methyl groups from histone proteins, playing a crucial role in epigenetic regulation. By inhibiting these enzymes, IOX1 can modulate gene expression and potentially impact various cellular processes. IOX1 has been widely used as a tool compound in research to study the functions and mechanisms of JmjC demethylases.

Reference

[1]. Held, D.M., et al., Differential susceptibility of HIV-1 reverse transcriptase to inhibition by RNA aptamers in enzymatic reactions monitoring specific steps during genome replication. J Biol Chem, 2006. 281(35): p. 25712-22.
[2]. Young, S.D., et al., L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother, 1995. 39(12): p. 2602-5.
[3]. Grobler, J.A., et al., HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro. J Biol Chem, 2007. 282(11): p. 8005-10.
[4]. Gatch, M.B., et al., The HIV antiretroviral drug efavirenz has LSD-like properties. Neuropsychopharmacology, 2013. 38(12): p. 2373-84.
[5]. Adjene, J.O., P.S. Igbigbi, and E.U. Nwose, Histological effects of chronic administration of efavirenz on lateral geniculate body of adult Wistar rats. N Am J Med Sci, 2010. 2(1): p. 1-4.