IOX4

For research use only. Not for therapeutic Use.

  • CAT Number: I011403
  • CAS Number: 1154097-71-8
  • Molecular Formula: C15H16N6O3
  • Molecular Weight: 328.33
  • Purity: ≥95%
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IOX4 (Cat No.:I011403) is a potent and selective inhibitor of the hypoxia-inducible factor (HIF) prolyl hydroxylase enzyme. It inhibits the degradation of HIF transcription factors, leading to the stabilization and accumulation of HIF-α subunits and subsequent activation of HIF-dependent gene expression. IOX4 has been extensively studied for its potential therapeutic applications in diseases associated with hypoxia, such as cancer and ischemic conditions. By targeting the HIF pathway, IOX4 may modulate cellular responses to low oxygen levels and promote adaptive mechanisms. Further research is being conducted to explore its therapeutic potential and assess its efficacy in various disease models.


Catalog Number I011403
CAS Number 1154097-71-8
Synonyms

IOX4

Molecular Formula C15H16N6O3
Purity ≥95%
Target HIF
Solubility Soluble in DMSO
Storage Store at -20°C
IUPAC Name tert-butyl 6-[3-oxo-4-(triazol-1-yl)-1H-pyrazol-2-yl]pyridine-3-carboxylate
InChI InChI=1S/C15H16N6O3/c1-15(2,3)24-14(23)10-4-5-12(16-8-10)21-13(22)11(9-18-21)20-7-6-17-19-20/h4-9,18H,1-3H3
InChIKey HWQQDVNGHZIALS-UHFFFAOYSA-N
SMILES CC(C)(C)OC(=O)C1=CN=C(C=C1)N2C(=O)C(=CN2)N3C=CN=N3
Reference

1: Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V,
Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura
A, Pugh CW, Ratcliffe PJ, Schofield CJ. Potent and Selective Triazole-Based
Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in
the Murine Brain. PLoS One. 2015 Jul 6;10(7):e0132004. doi:
10.1371/journal.pone.0132004. eCollection 2015. PubMed PMID: 26147748; PubMed
Central PMCID: PMC4492579.

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