For research use only. Not for therapeutic Use.
Iperoxo is a potent superagonist of muscarinic acetylcholine receptor (mAChR). [3H]Iperoxo can be used for direct probing activation-related conformational transitions of muscarinic receptors[1][2]. Iperoxo is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Catalog Number | I012554 |
| CAS Number | 247079-84-1 |
| Synonyms | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)but-2-ynyl-trimethylazanium;iodide |
| Molecular Formula | C10H17IN2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H17N2O2.HI/c1-12(2,3)7-4-5-8-13-10-6-9-14-11-10;/h6-9H2,1-3H3;1H/q+1;/p-1 |
| InChIKey | XWEOIAMCTHLJJB-UHFFFAOYSA-M |
| SMILES | C[N+](C)(C)CC#CCOC1=NOCC1.[I-] |
| Reference | [1]. Schrage R, et, al. Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor. Br J Pharmacol. 2013 May;169(2):357-70. [2]. Schrage R, et, al. New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo. Biochem Pharmacol. 2014 Aug 1;90(3):307-19. |
