IPO-3837

• CAT Number: I029469
• CAS Number: 99346-50-6
• Molecular Formula: C7H14N4O4
• Molecular Weight: 218.21
• Purity: 98%
• Synonyms: Azauracil diethanolamine salt; CCRIS 2713; Diethanolamine salt with 6-azauracil; IPO 3837; IPO3837; IPO-3837
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1,2,4-Triazine-3,5(2H,4H)-dione, compd. with 2,2'-iminobis(ethanol) (1:1)
• InChI: InChI=1S/C4H11NO2.C3H3N3O2/c6-3-1-5-2-4-7;7-2-1-4-6-3(8)5-2/h5-7H,1-4H2;1H,(H2,5,6,7,8)
• InChIKey: ZQXGMTGUSXHRSW-UHFFFAOYSA-N
• SMILES: OCCNCCO.O=C1NN=CC(=O)N1

IPO-3837(CAT: I029469) is a potent and selective inhibitor of fibroblast growth factor receptor 4 (FGFR4), extensively used in oncology research. By targeting FGFR4, it disrupts aberrant signaling pathways involved in tumor growth and progression, particularly in cancers driven by FGFR4 overexpression or dysregulation. IPO-3837 is instrumental in studying the molecular mechanisms of FGFR4-mediated signaling and its role in cancer biology. Its high specificity and efficacy make it an invaluable tool for preclinical studies and the development of targeted therapies for FGFR4-associated malignancies.