IpOHA

• CAT Number: I041089
• CAS Number: 132418-03-2
• Molecular Formula: C5H9NO4
• Molecular Weight: 147.13
• Purity: ≥95%
• Synonyms: 2-[hydroxy(propan-2-yl)amino]-2-oxoacetic acid
• InChI: InChI=1S/C5H9NO4/c1-3(2)6(10)4(7)5(8)9/h3,10H,1-2H3,(H,8,9)
• InChIKey: QVIOSGUKMDGWNN-UHFFFAOYSA-N
• SMILES: CC(C)N(C(=O)C(=O)O)O

IpOHA is a potent plant KARI inhibitor. IpOHA also is an antimycobacterial agent with a Ki value of 97.7 nM for Mycobacterium tuberculosis (Mt)[1].

Reference

[1]. Kandale A, et al. Analogues of the Herbicide, N-Hydroxy-N-isopropyloxamate, Inhibit Mycobacterium tuberculosis Ketol-Acid Reductoisomerase and Their Prodrugs Are Promising Anti-TB Drug Leads. J Med Chem. 2021 Feb 11;64(3):1670-1684.
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