For research use only. Not for therapeutic Use.
IpOHA (Cat No.: I041089) is a selective inhibitor of prolyl hydroxylase domain (PHD) enzymes, which regulate the stability of hypoxia-inducible factors (HIFs) under normoxic conditions. By inhibiting PHDs, IpOHA stabilizes HIF-α subunits, promoting the expression of hypoxia-responsive genes involved in angiogenesis, erythropoiesis, and cell survival. It is widely used in hypoxia signaling and oxygen-sensing pathway research, particularly in studies of ischemia, cancer, and metabolic regulation. IpOHA is for research use only in laboratory and preclinical investigations.
| CAS Number | 132418-03-2 |
| Synonyms | 2-[hydroxy(propan-2-yl)amino]-2-oxoacetic acid |
| Molecular Formula | C5H9NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C5H9NO4/c1-3(2)6(10)4(7)5(8)9/h3,10H,1-2H3,(H,8,9) |
| InChIKey | QVIOSGUKMDGWNN-UHFFFAOYSA-N |
| SMILES | CC(C)N(C(=O)C(=O)O)O |
| Reference | [1]. Kandale A, et al. Analogues of the Herbicide, N-Hydroxy-N-isopropyloxamate, Inhibit Mycobacterium tuberculosis Ketol-Acid Reductoisomerase and Their Prodrugs Are Promising Anti-TB Drug Leads. J Med Chem. 2021 Feb 11;64(3):1670-1684. |
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