For research use only. Not for therapeutic Use.
Ipriflavone（Cat No.:I007351）, marketed as Osteofix, is a small molecule substance utilized for the inhibition of bone resorption. It is commonly employed as a treatment for conditions associated with bone loss, such as osteoporosis. Ipriflavone works by suppressing the activity of osteoclasts, the cells responsible for breaking down bone tissue. By inhibiting bone resorption, it helps to maintain bone density and reduce the risk of fractures. Ipriflavone’s mechanism of action makes it valuable in the management of bone-related disorders characterized by excessive bone loss.
| Catalog Number | I007351 |
| CAS Number | 35212-22-7 |
| Synonyms | Ipriflavone; FL-113; FL 113; FL113; Yambolap; TC 80; TC-80; TC80;7-isopropoxy-3-phenyl-4H-chromen-4-one |
| Molecular Formula | C18H16O3 |
| Purity | ≥95% |
| Target | Osteoclast Inhibitor |
| Solubility | Soluble in DMSO |
| Storage | Room Temperature |
| IUPAC Name | (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol |
| InChI | InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3/b14-9+,15-11+ |
| InChIKey | CRDAMVZIKSXKFV-YFVJMOTDSA-N |
| SMILES | CC(=CCCC(=CCCC(=CCO)C)C)C |
| Reference | </br>1:Dietary supplementation with ipriflavone decreases hepatic iron stores in wild type mice. Patchen B, Koppe T, Cheng A, Seo YA, Wessling-Resnick M, Fraenkel PG.Blood Cells Mol Dis. 2016 Sep;60:36-43. doi: 10.1016/j.bcmd.2016.05.004. Epub 2016 May 8. PMID: 27519943 </br>2:The Protective and Therapeutic Effect of Exclusive and Combined Treatment with Alpha-ketoglutarate Sodium Salt and Ipriflavone on Bone Loss in Orchidectomized Rats. Radzki RP, Bieńko M, Filip R, Pierzynowski SG.J Nutr Health Aging. 2016;20(6):628-36. doi: 10.1007/s12603-015-0654-1. PMID: 27273352 </br>3:Evaluation of the Micellization Mechanism of an Amphipathic Graft Copolymer with Enhanced Solubility of Ipriflavone. Tanida S, Kurokawa T, Sato H, Kadota K, Tozuka Y.Chem Pharm Bull (Tokyo). 2016;64(1):68-72. doi: 10.1248/cpb.c15-00655. PMID: 26726747 Free Article</br>4:Low hygroscopic spray-dried powders with trans-glycosylated food additives enhance the solubility and oral bioavailability of ipriflavone. Fujimori M, Kadota K, Kato K, Seto Y, Onoue S, Sato H, Ueda H, Tozuka Y.Food Chem. 2016 Jan 1;190:1050-5. doi: 10.1016/j.foodchem.2015.06.081. Epub 2015 Jun 23. PMID: 26213075 </br>5:Ipriflavone reverses the adverse effects of a low-calcium diet on the histology of the tibia in caged layers. Lv WT, Yang YH, Ma LQ, Wang P, Li K.Br Poult Sci. 2014;55(2):207-14. doi: 10.1080/00071668.2013.878785. Epub 2014 Apr 24. PMID: 24404906 </br>6:Antimutagenic activity of ipriflavone against the DNA-damage induced by cyclophosphamide in mice. Delarmelina JM, Dutra JC, Batitucci Mdo C.Food Chem Toxicol. 2014 Mar;65:140-6. doi: 10.1016/j.fct.2013.12.028. Epub 2013 Dec 31. PMID: 24389340 Free Article</br>7:The neuroprotective effects of ipriflavone against H ₂O ₂ and amyloid beta induced toxicity in human neuroblastoma SH-SY5Y cells. Xiao Z, Huang C, Wu J, Sun L, Hao W, Leung LK, Huang J.Eur J Pharmacol. 2013 Dec 5;721(1-3):286-93. doi: 10.1016/j.ejphar.2013.09.023. Epub 2013 Sep 29. PMID: 24084576 </br>8:[Effect of ipriflavone on Wistar rats and their litters]. Bellei PM, Terra MM, Peters VM, Guerra Mde O, Andrade AT.Rev Bras Ginecol Obstet. 2012 Jan;34(1):22-7. Portuguese. PMID: 22358344 Free Article</br>9:Mutagenicity of ipriflavone in vivo and in vitro. Belcavello L, Vencioneck Dutra JC, de Freitas JV, Aranha IP, do Carmo Pimentel Batitucci M.Food Chem Toxicol. 2012 Mar;50(3-4):996-1000. doi: 10.1016/j.fct.2011.12.013. Epub 2011 Dec 17. PMID: 22200590 </br>10:Determination of ipriflavone in human plasma by LC-MS and its application in a pharmacokinetic study. Yun C, Ding L, Leng Y, Zhu H, Wen A, Yang L.Biomed Chromatogr. 2012 Jan;26(1):123-8. doi: 10.1002/bmc.1641. Epub 2011 May 19. PMID: 21594876 |
