IQ-1S free acid

• CAT Number: I002766
• CAS Number: 23146-22-7
• Molecular Formula: C15H9N3O
• Molecular Weight: 247.25
• Purity: ≥95%
• Target: JNK
• Solubility: Soluble to 20 mM in DMSO with gentle warming
• Storage: -20°C
• IUPAC Name: 11-nitroso-10H-indeno[1,2-b]quinoxaline
• InChI: InChI=1S/C15H9N3O/c19-18-14-10-6-2-1-5-9(10)13-15(14)17-12-8-4-3-7-11(12)16-13/h1-8,17H
• InChIKey: YSYIWCNPSZNNKW-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=C3C2=NC4=CC=CC=C4N3)N=O

IQ-1S free acid（Cat No.:I002766）is a selective inhibitor of c-Jun N-terminal kinase (JNK), a kinase involved in regulating cellular stress responses, apoptosis, and inflammation. By inhibiting JNK, IQ-1S prevents phosphorylation of c-Jun and subsequent activation of AP-1 transcription, which reduces inflammation and protects against cell damage. This compound has been studied for its potential neuroprotective effects, as JNK is implicated in neurodegenerative diseases like Alzheimer’s and Parkinson’s. IQ-1S is also used in cancer research to explore JNK’s role in tumor progression, making it a valuable tool for investigating JNK-mediated pathways.

Reference

[1]. Igor A. Schepetkin et al. Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor. J Pharmacol Exp Ther, 2015 Jun, 353(3): 505-516.

[2]. Dmitriy N. Atochin et al.A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice. Neurosci Lett.2016 Apr 8;618:45-9.

[3]. Igor A. Schepetkin et al. Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors. Mol Pharmacol, 2012 Jun, 81(6): 832-845.