IQ-R

• CAT Number: I001316
• CAS Number: 1345445-57-9
• Molecular Formula: C34H28N2O7
• Molecular Weight: 576.61
• Purity: ≥95%
• Solubility: 10 mM in H2O
• Storage: Store at -20°C
• IUPAC Name: (5-methoxy-1,2-dimethyl-4,7-dioxoindol-3-yl)methyl 2-[3-(dimethylamino)-6-oxoxanthen-9-yl]benzoate
• InChI: InChI=1S/C34H28N2O7/c1-18-25(31-32(36(18)4)26(38)16-29(41-5)33(31)39)17-42-34(40)22-9-7-6-8-21(22)30-23-12-10-19(35(2)3)14-27(23)43-28-15-20(37)11-13-24(28)30/h6-16H,17H2,1-5H3
• InChIKey: XAVOZQBGUYUYJD-UHFFFAOYSA-N
• SMILES: CC1=C(C2=C(N1C)C(=O)C=C(C2=O)OC)COC(=O)C3=CC=CC=C3C4=C5C=CC(=O)C=C5OC6=C4C=CC(=C6)N(C)C

IQ-R(CAT: I001316) is a cutting-edge hypoxia-sensitive fluorescent probe designed for detecting low-oxygen environments in biological systems. This innovative probe integrates an indolequinone unit and a rhodol fluorophore, enabling selective and responsive fluorescence activation under hypoxic conditions. The indolequinone moiety undergoes bioreduction in low-oxygen environments, triggering the rhodol fluorophore to emit a bright fluorescent signal. IQ-R is particularly valuable in cancer research, where it facilitates the visualization of tumor hypoxia, a key factor in tumor progression, metastasis, and resistance to therapy. Its precise sensitivity and versatility make it an essential tool for studying hypoxia-related cellular mechanisms and drug development.