IQDMA

• CAT Number: I029486
• CAS Number: 401463-02-3
• Molecular Formula: C19H20N4
• Molecular Weight: 304.4
• Purity: 98%
• Synonyms: C524250; IQDMA cpd; IQDMA
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N'-(11H-Indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine
• InChI: InChI=1S/C19H20N4/c1-23(2)12-11-20-19-17-13-7-3-5-9-15(13)21-18(17)14-8-4-6-10-16(14)22-19/h3-10,21H,11-12H2,1-2H3,(H,20,22)
• InChIKey: UROLFQZUYMCOHV-UHFFFAOYSA-N
• SMILES: CN(C)CCNC1=NC2=CC=CC=C2C3=C1C4=C(N3)C=CC=C4

IQDMA is an inhibitor of the transcription factor STAT5.

Reference

1: Su JC, Lin KL, Chien CM, Lu CM, Chen YL, Chang LS, Lin SR. Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation. Life Sci. 2009 Sep 23;85(13-14):505-16. doi: 10.1016/j.lfs.2009.08.006. Epub 2009 Aug 21. PubMed PMID: 19699753.
2: Yang SH, Chien CM, Su JC, Chen YL, Chang LS, Lin SR. Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells. J Biochem Mol Toxicol. 2008 Nov-Dec;22(6):396-404. doi: 10.1002/jbt.20254. PubMed PMID: 19111001.
3: Chien CM, Yang SH, Lin KL, Chen YL, Chang LS, Lin SR. Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells. Chem Biol Interact. 2008 Oct 22;176(1):40-7. doi: 10.1016/j.cbi.2008.06.008. Epub 2008 Jun 28. PubMed PMID: 18638462.
4: Yang SH, Chien CM, Lu CM, Chen YL, Chang LS, Lin SR. Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells. Leuk Res. 2007 Oct;31(10):1413-20. Epub 2007 Mar 29. PubMed PMID: 17397922.
5: Hu XW, Chien CM, Yang SH, Lin YH, Lu CM, Chen YL, Lin SR. A novel indoloquinoline derivative, IQDMA, induces S-phase arrest and apoptosis in promyelocytic leukemia HL-60 cells. Cell Biol Toxicol. 2006 Nov;22(6):417-27. Epub 2006 Aug 13. PubMed PMID: 16906476.