IR-825

• CAT Number: I007357
• CAS Number: 1558079-49-4
• Molecular Formula: C54H48BrClN2O4
• Molecular Weight: 904.342
• Purity: ≥95%
• Synonyms: IR-825; IR825; IR825.;3-(4-carboxybenzyl)-2-((E)-2-((E)-3-((Z)-2-(3-(4-carboxybenzyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)ethylidene)-2-chlorocyclohex-1-en-1-yl)vinyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term , or -20°C for long term.
• SMILES: CC1(C)C(/C=C/C2=C(Cl)/C(CCC2)=C/C=C3C(C)(C4=C(C=CC5=CC=CC=C54)N/3CC6=CC=C(C(O)=O)C=C6)C)=[N+](CC7=CC=C(C(O)=O)C=C7)C8=C1C9=CC=CC=C9C=C8

IR-825 (CAT: I007357) is a near-infrared (NIR) dye with potential applications in cancer photothermal and photodynamic therapy. When encapsulated into nanoparticles, IR-825 exhibits pH-dependent fluorescence emission, making it a versatile tool for imaging and targeting cancer cells. This unique property allows for precise monitoring and therapeutic intervention. Upon NIR irradiation, IR-825 nanoparticles exhibit excellent photothermal and photodynamic effects, leading to localized cytotoxicity in targeted cancer cells.

Reference

1:Islamy Mazrad ZA, In I, Lee KD, Park SY. Rapid fluorometric bacteria detection assay and photothermal effect by fluorescent polymer of coated surfaces and aqueous state. Biosens Bioelectron. 2016 Oct 14. pii: S0956-5663(16)31034-X. doi: 10.1016/j.bios.2016.10.027. [Epub ahead of print] PubMed PMID: 27825519.