IRAK-4 protein kinase inhibitor 2

• CAT Number: I045036
• CAS Number: 301675-24-1
• Molecular Formula: C14H10N4O3
• Molecular Weight: 282.25
• Purity: ≥95%
• Synonyms: N-(1H-benzimidazol-2-yl)-3-nitrobenzamide
• InChI: InChI=1S/C14H10N4O3/c19-13(9-4-3-5-10(8-9)18(20)21)17-14-15-11-6-1-2-7-12(11)16-14/h1-8H,(H2,15,16,17,19)
• InChIKey: QPKROMNIEAEFQA-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)NC(=N2)NC(=O)C3=CC(=CC=C3)[N+](=O)[O-]

IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders[1].
IRAK-4 protein kinase inhibitor 2 (compound 1) also inhibits IRAK-1, with an IC50 of <10 μM[1].

Reference

[1]. Powers JP, et, al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5.
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