For research use only. Not for therapeutic Use.
IRAK4-IN-22（Cat No.:I042858）is a small molecule inhibitor targeting interleukin-1 receptor-associated kinase 4 (IRAK4), an essential enzyme in the signaling pathways of the immune response. IRAK4 plays a critical role in inflammation and immune system activation, particularly in response to pathogen recognition. By inhibiting IRAK4, IRAK4-IN-22 can suppress the activation of downstream pro-inflammatory cytokines, offering potential therapeutic applications in autoimmune diseases, chronic inflammation, and certain cancers. Preclinical studies suggest that IRAK4-IN-22 may effectively modulate immune responses, with ongoing research exploring its safety, efficacy, and clinical potential.
| CAS Number | 2170694-05-8 |
| Synonyms | (1S,2S,3R,4R)-3-[[5-(2-fluoropyridin-4-yl)-2-[3-(pyrrolidine-1-carbonyl)anilino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide |
| Molecular Formula | C28H28FN7O2 |
| Purity | ≥95% |
| IUPAC Name | (1S,2S,3R,4R)-3-[[5-(2-fluoropyridin-4-yl)-2-[3-(pyrrolidine-1-carbonyl)anilino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide |
| InChI | InChI=1S/C28H28FN7O2/c29-22-14-16(8-9-31-22)21-15-32-28(33-20-5-3-4-19(13-20)27(38)36-10-1-2-11-36)35-26(21)34-24-18-7-6-17(12-18)23(24)25(30)37/h3-9,13-15,17-18,23-24H,1-2,10-12H2,(H2,30,37)(H2,32,33,34,35)/t17-,18+,23+,24-/m1/s1 |
| InChIKey | FLZAOAIEJUXTAH-HJOCRKTISA-N |
| SMILES | C1CCN(C1)C(=O)C2=CC(=CC=C2)NC3=NC=C(C(=N3)N[C@@H]4[C@@H]5C[C@H]([C@@H]4C(=O)N)C=C5)C6=CC(=NC=C6)F |
