Irbesartan D4

• CAT Number: I000822
• CAS Number: 1216883-23-6
• Molecular Formula: C25H24D4N6O
• Molecular Weight: 432.55
• Purity: ≥95%
• Target: Angiotensin Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at +4C
• IUPAC Name: 2-butyl-3-[[2,3,5,6-tetradeuterio-4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
• InChI: InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)/i11D,12D,13D,14D
• InChIKey: YOSHYTLCDANDAN-WQKXEYJYSA-N
• SMILES: [2H]C1=C(C(=C(C(=C1CN2C(=NC3(C2=O)CCCC3)CCCC)[2H])[2H])C4=CC=CC=C4C5=NNN=N5)[2H]

Irbesartan D4 is an isotopically labeled form of irbesartan, a medication commonly used to manage hypertension and treat diabetic nephropathy. Enhanced with four deuterium atoms, this compound provides distinct advantages for pharmacokinetic and metabolic studies. The deuterium atoms replace hydrogen in key positions, which increases the molecular stability of irbesartan, reducing its metabolic degradation. This makes Irbesartan D4 highly useful for tracing the absorption, distribution, metabolism, and excretion (ADME) of irbesartan in the human body using advanced analytical techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. It is an essential tool for researchers looking to understand the drug’s behavior in biological systems, ultimately aiding in the optimization of therapeutic regimes.