For research use only. Not for therapeutic Use.
A potent inhibitor of the endonuclease IRE1 (IC50 = 6.3 nM) and unfolded protein response (UPR)
| CAS Number | 626221-47-4 |
| Molecular Formula | C16H13F3N4OS2 |
| Purity | ≥95% |
| IUPAC Name | 2-[[3-cyano-4-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide |
| InChI | InChI=1S/C16H13F3N4OS2/c1-8-6-26-15(21-8)23-12(24)7-25-14-10(5-20)13(16(17,18)19)9-3-2-4-11(9)22-14/h6H,2-4,7H2,1H3,(H,21,23,24) |
| SMILES | CC1=CSC(=N1)NC(=O)CSC2=NC3=C(CCC3)C(=C2C#N)C(F)(F)F |
| Reference | D Feldman and AC Koong. Irestatin, a potent inhibitor of IRE1α and the unfolded protein response, is a hypoxia-selective cytotoxin and impairs tumor growth. J. Clin. Oncol. (2007 ASCO Ann. Meeting Proc. PI) 2007, 25 (18S), 3514. |
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