IRG1-IN-1

• CAT Number: I042626
• CAS Number: 2407652-42-8
• Molecular Formula: C18H15FO4
• Molecular Weight: 314.31
• Purity: ≥95%
• Synonyms: (3Z)-2-benzyl-3-[(4-fluorophenyl)methylidene]butanedioic acid
• InChI: InChI=1S/C18H15FO4/c19-14-8-6-13(7-9-14)11-16(18(22)23)15(17(20)21)10-12-4-2-1-3-5-12/h1-9,11,15H,10H2,(H,20,21)(H,22,23)/b16-11-
• InChIKey: DZXOXUPVMSOERA-WJDWOHSUSA-N
• SMILES: C1=CC=C(C=C1)CC(/C(=C/C2=CC=C(C=C2)F)/C(=O)O)C(=O)O

IRG1-IN-1（Cat No.:I042626）is a small molecule inhibitor designed to target immune-responsive gene 1 (IRG1), an enzyme involved in the regulation of immune responses, particularly in macrophages. IRG1 plays a role in the production of itaconate, a metabolite that modulates inflammation and immune cell function. By inhibiting IRG1, IRG1-IN-1 aims to alter metabolic pathways in immune cells, potentially reducing excessive inflammation and improving outcomes in conditions like autoimmune diseases, chronic inflammation, and certain cancers. Ongoing research is focused on evaluating its therapeutic potential, efficacy, and safety in preclinical and clinical settings.