For research use only. Not for therapeutic Use.
IRL2500（Cat No.:I007361） is a potent endothelin receptor (Endothelin receptor) antagonist with IC50 values of 1.3 and 94nM for ETB and ETA receptors, respectively. IRL2500 inhibits ETB receptor-mediated blood pressure elevation and renal vascular resistance in vivo.
| Catalog Number | I007361 |
| CAS Number | 169545-27-1 |
| Synonyms | IRL-2500; IRL 2500; IRL2500.;((R)-3-([1,1/’-biphenyl]-4-yl)-2-(N,3,5-trimethylbenzamido)propanoyl)-L-tryptophan |
| Molecular Formula | C36H35N3O4 |
| Purity | ≥95% |
| Target | Endothelin Receptor |
| Solubility | Soluble in DMSO, not in water |
| Storage | -20°C |
| IUPAC Name | (2S)-2-[[(2R)-2-[(3,5-dimethylbenzoyl)-methylamino]-3-(4-phenylphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoic acid |
| InChI | InChI=1S/C36H35N3O4/c1-23-17-24(2)19-28(18-23)35(41)39(3)33(20-25-13-15-27(16-14-25)26-9-5-4-6-10-26)34(40)38-32(36(42)43)21-29-22-37-31-12-8-7-11-30(29)31/h4-19,22,32-33,37H,20-21H2,1-3H3,(H,38,40)(H,42,43)/t32-,33+/m0/s1 |
| InChIKey | UZDORQWMYRRLQV-JHOUSYSJSA-N |
| SMILES | CC1=CC(=CC(=C1)C(=O)N(C)C(CC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)O)C |
| Reference | </br>1:Use of A-192621 and IRL-2500 to unmask the mesenteric and renal vasodilator role of endothelin ET(B) receptors. Leung SW, Lim SL, Pang CC, Man RY.J Cardiovasc Pharmacol. 2002 Apr;39(4):533-43. PMID: 11904527 </br>2:Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500. Balwierczak JL, Bruseo CW, DelGrande D, Jeng AY, Savage P, Shetty SS.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S393-6. PMID: 8587424 </br>3:Effects of the ETB-selective antagonist IRL 2500 in conscious spontaneously hypertensive and Wistar-Kyoto rats. Webb RL, Navarrete AE, Ksander GM.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S389-92. PMID: 8587423 |
