For research use only. Not for therapeutic Use.
ISAM-140 (22b) is a potent and highly selective A2B adenosine receptor antagonist with a Ki of 3.49 nM[1].
ISAM-140 (22b) (0.1-100 µM) inhibits NECA (5′-N-ethylcarboxamido adenosine)-stimulated cAMP accumulation[1].
ISAM-140 shows a KB value of 27.00 nM[1].
| Catalog Number | I011350 |
| CAS Number | 932191-62-3 |
| Synonyms | propan-2-yl 4-(furan-2-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate |
| Molecular Formula | C19H19N3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H19N3O3/c1-11(2)25-18(23)16-12(3)20-19-21-13-7-4-5-8-14(13)22(19)17(16)15-9-6-10-24-15/h4-11,17H,1-3H3,(H,20,21) |
| InChIKey | NYHLRBMDXQBOIB-UHFFFAOYSA-N |
| SMILES | CC1=C(C(N2C3=CC=CC=C3N=C2N1)C4=CC=CO4)C(=O)OC(C)C |
| Reference | [1]. El Maatougui A, et al. Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes. J Med Chem. 2016 Mar 10;59(5):1967-83. |
